Fluorescence Endoscope Perfusion Control for Heat Denaturation
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Solution Overview
Problem
Existing technologies lack effective methods for visualizing the state of heat denaturation in body tissue during energy-based treatments and controlling perfusion devices to manage tissue cooling based on this visualization.
Innovation Solution
A medical device and endoscope system that captures fluorescence from body tissue using excitation light, determines variations in heat denaturation, and controls a perfusion device to perfuse a perfusate based on these variations, utilizing a processor to generate images and send control signals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescence imaging is used to visualize heat denaturation, then measurement precision of heat denaturation state is improved, but device complexity increases due to additional imaging and processing systems
Solution Approach 1:
The patent combines the fluorescence imaging system with the existing energy treatment device and perfusion device into an integrated system. The imaging device captures fluorescence images of the treatment area, and the control unit processes these images to determine heat denaturation state, then controls the perfusion device based on this information. This merging approach allows the system to achieve precise heat denaturation visualization while managing complexity through functional integration.
Solution Approach 2:
The system implements a feedback loop where the control unit continuously monitors fluorescence images to detect heat denaturation state, adjusts perfusion rate accordingly, and repeats the process. The feedback mechanism uses the captured fluorescence images to determine the state of heat denaturation, then controls the perfusion device to adjust cooling based on this real-time information, enabling precise control of the treatment process.
2Reliability
If real-time monitoring of heat denaturation is implemented, then reliability of tissue management is improved, but loss of time increases due to imaging and processing requirements
Solution Approach 1:
The system performs continuous fluorescence imaging and real-time processing to monitor heat denaturation throughout the energy treatment process. The control unit continuously captures images, processes them to determine heat denaturation state, and adjusts perfusion rate without interruption. This continuous monitoring ensures reliable tissue management while minimizing time loss by eliminating gaps in observation.
Solution Approach 2:
The system performs preliminary imaging and processing before the energy treatment begins, establishing a baseline of the treatment area's fluorescence characteristics. This preliminary action allows the system to quickly compare subsequent images against the baseline, reducing the time needed for real-time analysis and enabling faster response to heat denaturation changes.
3Ease of operation
If automated perfusion control based on fluorescence imaging is implemented, then ease of operation is improved, but device complexity increases due to integration of multiple control systems
Solution Approach 1:
The system implements self-service automation where the control unit automatically processes fluorescence images, determines heat denaturation state, and controls the perfusion device without requiring manual intervention. The automated perfusion control adjusts the perfusion rate based on real-time fluorescence imaging data, eliminating the need for operator judgment and manual adjustment, thereby improving ease of operation.
Solution Approach 2:
The control unit serves multiple functions: it processes fluorescence images, determines heat denaturation state, controls the energy treatment device, and regulates the perfusion device. This multi-functionality reduces the need for separate dedicated systems for each function, managing overall device complexity while maintaining automated operation across all subsystems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise control of perfusion to cool body tissue appropriately, managing heat denaturation effects during procedures like transurethral uretero-lithotripsy, ensuring effective tissue management and safety.
Implementation Method 1
capturing fluorescence generated from a body tissue as a result of irradiation of an excitation light on the body tissue
Data Source
AI summary
A medical device includes a processor including hardware, the processor being configured to: generate a taken image by capturing fluorescence generated from a body tissue as a result of irradiation of an excitation light on the body tissue, determine variation in state of heat denaturation based on the taken image, and send a control signal for controlling an operation of a perfusion device configured to perfuse a perfusate, to the perfusion device, based on a result of determination about the variation in the state of heat denaturation.