Fluorescence Image Tone Expansion for Photoimmunotherapy Monitoring
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Solution Overview
Problem
Current image processing techniques for fluorescence images in photoimmunotherapy (PIT) struggle to effectively enhance and display the dynamic range of fluorescence intensity changes, making it difficult to accurately assess treatment progress and effectiveness, especially when fluorescence intensity decreases during therapeutic light irradiation.
Innovation Solution
An image processing apparatus and method that acquires fluorescence images, sets a tone adjustment range based on the occurrence frequency of fluorescence intensity, and allocates tones within this range to generate a tone-expanded image, enhancing the visibility of fluorescence intensity changes and facilitating the assessment of treatment progress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional image processing techniques are used for fluorescence images, then the processing is simple and fast, but the dynamic range of fluorescence intensity changes cannot be effectively enhanced
Solution Approach 1:
The patent applies parameter changes by dynamically adjusting the tone adjustment range based on the occurrence frequency distribution of fluorescence intensity values. The processor calculates the distribution of fluorescence intensities and sets the tone adjustment range to cover frequencies from a predetermined lower limit to a maximum value, thereby expanding the dynamic range to effectively display both high and low intensity regions.
2Measurement precision
If the full range of fluorescence intensity is displayed, then all intensity levels are visible, but subtle intensity differences become difficult to distinguish
Solution Approach 1:
The patent applies local quality by differentiating the tone allocation strategy across different frequency ranges. For fluorescence intensities with occurrence frequencies between the lower limit and maximum, tones are allocated according to the calculated distribution. For intensities above the maximum frequency, a predetermined tone allocation is used, ensuring both subtle differences and overall structure are preserved.
3Measurement precision
If tone adjustment range is expanded to cover all fluorescence intensities, then the full dynamic range is visible, but the contrast of important features is reduced
Solution Approach 1:
The patent applies dynamics by making the tone adjustment range adaptive rather than fixed. The processor continuously calculates the occurrence frequency distribution of fluorescence intensities and dynamically adjusts the tone adjustment range accordingly, allowing the system to adapt to varying fluorescence conditions while maintaining optimal contrast and resolution.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for accurate visualization and monitoring of fluorescence intensity changes, enabling better evaluation of treatment effectiveness and progress, even when fluorescence intensity decreases, by expanding the dynamic range and highlighting subtle intensity differences.
Implementation Method 1
acquire a fluorescence image obtained by therapeutic light that causes a drug to react
Data Source
AI summary
Provided is an image processing apparatus that processes a fluorescence image signal. The image processing apparatus includes a processor including hardware, the processor being configured to: acquire a fluorescence image obtained by therapeutic light that causes a drug to react; set a fluorescence intensity signal in which an occurrence frequency of a fluorescence intensity of the fluorescence image is equal to or higher than a threshold to a tone adjustment range of an image; and allocate tones according to the set tone adjustment range to generate a tone-expanded image.