Fluorescent Agent Concentration Measuring Apparatus for Peak Timing Estimation
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Solution Overview
Problem
Current methods for diagnosing and treating diseases using fluorescent agents, such as cancer, face challenges in accurately determining the peak concentration of these agents in the body and maintaining stable fluorescence intensity for effective observation, leading to inefficiencies in diagnosis and treatment.
Innovation Solution
A fluorescent agent concentration measuring apparatus that calculates the peak timing of accumulation concentration using an excitation light source, fluorescence detection, and peak time estimation, integrated with a dose control apparatus for stable fluorescence observation, improving diagnostic performance and reducing observation time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescent agents are administered to diagnose and treat diseases, then diagnostic capability is improved, but accurate determination of peak concentration and stable fluorescence intensity cannot be maintained
Solution Approach 1:
The system continuously monitors fluorescence intensity from the fluorescent agent in the body and feeds this information back to the dose control apparatus. Based on this feedback, the system automatically adjusts the administered dose to maintain stable fluorescence intensity and achieve peak concentration at the desired observation time, thereby resolving the contradiction between accurate peak determination and intensity stability.
Solution Approach 2:
The system dynamically changes the dosage parameters of the fluorescent agent based on real-time fluorescence intensity measurements. By adjusting the dose amount and administration timing according to measured parameters, the system achieves both accurate peak concentration determination and stable fluorescence intensity for effective observation.
2Measurement precision
If fluorescent agents are administered for disease diagnosis, then diagnostic capability is improved, but observation time increases and diagnostic efficiency decreases
Solution Approach 1:
The system performs preliminary measurements of fluorescence intensity at multiple time points after fluorescent agent administration to predict the peak concentration timing in advance. This preliminary action allows the system to determine the optimal observation time before actual diagnosis, thereby improving diagnostic efficiency without sacrificing accuracy.
Solution Approach 2:
By continuously monitoring fluorescence intensity and providing feedback to determine peak concentration timing, the system eliminates the need for prolonged observation periods. The feedback mechanism enables rapid identification of the optimal diagnostic window, thus improving diagnostic efficiency while maintaining high measurement precision.
3Device complexity
If manual dose administration is used, then system simplicity is maintained, but stable fluorescence observation and peak concentration control cannot be achieved
Solution Approach 1:
The dose control apparatus performs self-service by automatically calculating the required dose and administration timing based on real-time fluorescence intensity measurements. The system uses the measured fluorescence data to autonomously determine peak concentration timing and adjust subsequent dosing, eliminating the need for complex manual intervention while maintaining observation stability.
Solution Approach 2:
The system incorporates an automatic feedback loop where fluorescence intensity measurements are continuously fed back to the dose control apparatus, which then automatically adjusts the administered dose. This feedback mechanism enables stable fluorescence observation and reliable peak concentration control without requiring complex manual dose adjustment procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The apparatus enables precise estimation of peak fluorescent agent concentration and stable fluorescence intensity, enhancing diagnostic accuracy and efficiency by optimizing the administration timing and dose of fluorescent drugs.
Implementation Method 1
an excitation light source for radiating excitation light to a sample containing a body fluid taken from a living body administered with a fluorescent drug, the excitation light allowing the drug to emit fluorescence
Data Source
AI summary
A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 26 to compare the detection result from the detection processing circuit with an analytical pattern stored in a pattern storage portion and calculate the peak time of the accumulation concentration in a tissue of a sample in the test bottle.