Fluorescent Particle Tissue-Marking Agent with Stable Dispersion
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Solution Overview
Problem
Existing tissue-marking agents using fluorescent dye-labelled particles in an aqueous medium suffer from low dispersion stability, leading to concentration gradients and needle blockages during administration, making it difficult to accurately mark tumor sites.
Innovation Solution
Dispersing fine particles labelled with a fluorescent dye in an aqueous medium containing a water-soluble viscous substance, such as polysaccharides or polyhydric alcohols, improves dispersion stability and prevents needle blockage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If fine particles labelled with fluorescent dye are dispersed in simple aqueous medium, then the preparation is simple, but dispersion stability is low causing concentration gradients and needle blockage
Solution Approach 1:
A water-soluble viscous substance is introduced as an intermediary component in the aqueous medium to improve particle dispersion stability. This mediator prevents particle aggregation and maintains uniform distribution during storage and administration, eliminating concentration gradients and needle blockage while preserving preparation simplicity
Solution Approach 2:
The physical parameters of the aqueous medium are modified by adjusting viscosity through the addition of water-soluble viscous substances. This parameter change enhances dispersion stability and prevents particle settling without significantly complicating the preparation process
2Ease of manufacture
If indocyanine green is used as tissue-marking agent, then fluorescent marking is achieved, but rapid diffusion occurs making it ineffective
Solution Approach 1:
Indocyanine green is combined with fine particles to create a composite material system. The fluorescent dye is attached to or adsorbed on particle surfaces, creating a composite that maintains the fluorescent marking capability while the particle structure prevents rapid diffusion and enhances localization stability at the tumor site
Solution Approach 2:
The fluorescent marking agent is localized to specific particle structures that remain confined to the injection site. This local quality approach ensures the marking remains at the target location without diffusing into surrounding tissues, maintaining both marking effectiveness and localization stability
3Duration of action of stationary object
If silica nanoparticles with ICG are dispersed in water, then marking duration extends to 12 days, but dispersion stability is not considered
Solution Approach 1:
A water-soluble viscous substance serves as an intermediary to improve the dispersion stability of silica nanoparticles in aqueous medium. This mediator maintains uniform particle distribution throughout the extended 12-day marking period, preventing aggregation and ensuring consistent performance over time
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the administration of a consistent amount of the tissue-marking agent, ensuring accurate and prolonged marking of tumor sites without needle obstruction.
Implementation Method 1
dispersing fine particles labelled with a fluorescent dye in an aqueous medium containing a water-soluble viscous substance improves dispersion stability
Implementation Method 2
fine particles labelled with a fluorescent dye
Data Source
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AI summary
Provided is a tissue-marking agent that improves the dispersion stability of fine particles labelled with a fluorescent dye in an aqueous medium. The present invention involves dispersing fine particles labelled with a fluorescent dye in an aqueous medium containing a water-soluble viscous substance.