Fluorescent Particle with Gold Nanoparticle Core and Lanthanide Complex
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Solution Overview
Problem
Current fluorescent particles used for biomaterial analysis lack visibility under naked eye detection and require significant sample amounts for effective analysis.
Innovation Solution
Development of fluorescent particles comprising a gold nanoparticle core, a silica shell, and lanthanide group complex particles dispersed within the silica shell, which include lanthanide ions bonded with phosphorus-containing ligands and beta diketone functional groups, allowing for visible light emission and enhanced fluorescence characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional fluorescent particles are used for biomaterial analysis, then analysis sensitivity is improved, but visibility under naked eye detection deteriorates
Solution Approach 1:
The patent creates a composite fluorescent particle consisting of a silica core, gold nanoparticle shell, and lanthanide complex coating. This composite structure combines the high fluorescence quantum yield of lanthanide complexes with the surface plasmon resonance enhancement from gold nanoparticles, achieving both high analysis sensitivity and strong naked-eye visibility under UV irradiation
Solution Approach 2:
The patent merges three distinct fluorescent mechanisms into one particle system: silica-based fluorescence, gold nanoparticle surface plasmon resonance, and lanthanide complex fluorescence. This merging of multiple fluorescent components synergistically enhances both the sensitivity for biomaterial analysis and the visibility for naked-eye detection
2Measurement precision
If conventional fluorescent particles are used for biomaterial analysis, then detection capability is improved, but sample amount requirement deteriorates
Solution Approach 1:
The patent modifies key parameters of the fluorescent particle including the core size (50-200 nm), gold shell thickness (5-50 nm), and lanthanide complex concentration. These parameter optimizations maximize the fluorescence quantum yield and surface plasmon resonance effect, enabling detection of biomaterials at extremely low concentrations with high detection capability while minimizing the required sample amount
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The particles enable detection of biosamples with the naked eye and improve analysis sensitivity by emitting light in the visible region, allowing for analysis of small biomaterial amounts without toxicity, with adjustable wavelength and intensity.
Implementation Method 1
A fluorescent particle including metal such as gold or silver has a fluorescent characteristic improved due to a surface plasmon resonance phenomenon
Implementation Method 2
Fluorescence occurs when electrons are emitted by electron transference while a material in an excited state returns to the material in a bottom state by absorbing photons by molecules
Data Source
AI summary
Provided are a fluorescent particle and a method for manufacturing the same. The fluorescent particle may include a gold nanoparticle; a silica shell covering the gold nanoparticle; and lanthanide group complex particles dispersed in the silica shell. Each of the lanthanide group complex particles may include a lanthanide group ion; a ligand bonded to the lanthanide group ion and including phosphorus; and a ligand bonded to the lanthanide group ion and having a beta diketone functional group. The fluorescent particle is observable with the naked eye and may emit light when ultraviolet light is irradiated. The fluorescent particle may be used for detecting and analyzing biomaterial samples.