Fluorescent-Probe Solvent Composition to Suppress Storage Purity Loss
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Solution Overview
Problem
The purity of fluorescent probes used for cancer detection is reduced during storage, posing a challenge for their practical application.
Innovation Solution
A fluorescent-probe solution comprising a compound represented by formula (I) or its salt, mixed with specific organic solvents like dimethyl sulfoxide and water, within defined volume percentages, enhances stability and maintains purity over time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If the fluorescent probe is stored in organic solvent, then the probe can be dissolved and maintained in solution, but the purity of the probe is reduced during storage
Solution Approach 1:
The patent changes the solvent composition parameters by using a mixed solvent system consisting of organic solvent (5-95 vol%) and water (5-95 vol%), rather than pure organic solvent. This parameter change resolves the contradiction by maintaining probe purity while enabling long-term storage stability.
Solution Approach 2:
The patent employs a composite solvent system combining organic solvent and water in specific proportions. This composite approach allows the fluorescent probe to maintain both solubility (from organic solvent) and stability/purity (from water component) during storage.
2Stability of the object's composition
If water is added to the fluorescent probe solution, then the purity reduction is suppressed, but the solubility may be affected
Solution Approach 1:
The patent optimizes the water content parameter within the range of 5-95 vol% to achieve the desired balance. By controlling this parameter, the solution maintains both purity enhancement and adequate solubility for practical applications.
Solution Approach 2:
The patent applies local quality by having different regions of the solvent system serve different functions: the organic solvent component provides solubility while the water component provides purity stabilization. This functional differentiation resolves the contradiction between these two properties.
Data Source
AI summary
A fluorescent-probe solution in which a reduction in purity of a fluorescent probe is suppressed. The fluorescent-probe solution includes: a compound represented by the formula (I) or a salt thereof; at least one kind of organic solvent selected from the group consisting of: dimethyl sulfoxide; an alcohol having 1 to 3 carbon atoms; and N,N-dimethylformamide; and water. A content of the organic solvent is from 5 vol % to 95 vol %, and a content of the water is from 5 vol % to 95 vol %.