Fluorescent Standard Strip for Analyzer Calibration
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Solution Overview
Problem
Conventional fluorescence analysis devices experience inter-device deviations in intensity due to electromagnetic component variations, leading to unreliable results and fluorescence quenching, making it difficult to maintain consistent performance across multiple devices.
Innovation Solution
A fluorescent standard strip with a substrate, a fluorescent layer, and a masking layer that partially blocks fluorescence, ensuring a higher intensity of fluorescence and minimizing deterioration over time, even under frequent light irradiation, by controlling the transmission of fluorescence through a patterned light transmitting and blocking portion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a fluorescent substance is used in conventional analysis devices, then fluorescence signal can be obtained, but inter-device deviation in intensity occurs due to electromagnetic component variations
Solution Approach 1:
The patent introduces a fluorescent standard strip as an intermediary reference object between the light source and the test sample. This standard strip contains a fluorescent substance with known characteristics that serves as a mediator to calibrate and normalize measurements across different devices, eliminating inter-device deviation caused by electromagnetic component variations
Solution Approach 2:
The patent changes the parameters of the fluorescent standard strip specifically - using a fluorescent substance with higher intensity than test samples, controlling its emission wavelength to fall within the detection range, and adjusting its concentration to provide optimal reference signals. These parameter optimizations ensure reliable calibration while maintaining measurement precision
2Measurement precision
If conventional fluorescent substances are used for standard strips, then fluorescence signal can be obtained, but fluorescence quenching occurs causing intensity decrease over time
Solution Approach 1:
The patent optimizes parameters of the fluorescent substance in the standard strip by selecting substances with higher quantum yield and photostability, controlling their concentration to avoid self-quenching, and adjusting excitation wavelengths to minimize photodegradation. These parameter changes enable the standard strip to maintain stable fluorescence intensity for extended periods
Solution Approach 2:
The patent applies protective measures beforehand by incorporating antioxidants and stabilizing agents in the fluorescent standard strip formulation, and by optimizing the physical and chemical environment of the fluorescent substance to prevent quenching. This prior cushioning protects against fluorescence intensity decrease over time
3Productivity
If frequent light irradiation is applied to fluorescent standard strips, then measurement can be performed, but fluorescence intensity deteriorates due to quenching
Solution Approach 1:
The patent changes parameters including using fluorescent substances with higher photostability, optimizing excitation light intensity and wavelength to reduce photodegradation, and adjusting the chemical composition of the standard strip matrix to protect against light-induced quenching. These changes enable frequent measurements without significant intensity loss
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution reduces inter-device deviations, maintains a linear fluorescent signal characteristic, and allows for periodic testing of device reliability, ensuring consistent performance and minimizing fluorescence intensity loss over time.
Implementation Method 1
a fluorescent substance is used in an analysis device using a fluorescence analysis method
Implementation Method 2
a masking layer stacked on the fluorescent layer to partially block fluorescence exposed to the outside from the fluorescent layer
Data Source
AI summary
A fluorescent standard strip, according to the present invention, is for testing the reliability of the fluorescence intensity of a fluorescent strip used for an analyzer, the fluorescent standard strip having an effect whereby, for devices using a fluorescent substance, the inter-device deviation in fluorescence intensity is reduced, fluorescent signal linearity per fluorescent concentration level is secured, and device reliability may be tested by periodically checking faults, errors, deviations, etc. of the devices. In addition, the fluorescent standard strip, according to the present invention, has an effect whereby, even in an environment and state where light is frequently irradiated, the reduction of fluorescence intensity according to time may be minimized, i.e., the same level of fluorescence intensity may be maintained for a long period.