Fluoride Oral Care Composition Using Nonwoven Phase Separation
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Solution Overview
Problem
Fluoride ion sources in oral care compositions face challenges due to reactivity with other ingredients, leading to altered bioavailability and reduced efficacy, necessitating a formulation that minimizes reactivity and ensures rapid release and dispersal in the oral cavity.
Innovation Solution
The use of nonwoven webs to physically separate fluoride ions from other reactive components, such as calcium ions, in discrete phases within the oral care composition, ensuring minimal reactivity and enhanced fluoride uptake.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fluoride ion sources are incorporated into dentifrice compositions, then anticaries benefits are delivered through fluoride uptake into enamel, but reactivity between fluoride ions and other dentifrice components (such as calcium ions) significantly alters fluoride bioavailability
Solution Approach 1:
The dentifrice composition is divided into discrete phases: a fibrous phase containing fluoride ion source and a non-fibrous phase containing calcium ion source. This segmentation physically separates reactive components during storage, preventing unwanted reactions that would reduce fluoride bioavailability, while still allowing both components to be present in the final product for anticaries efficacy.
Solution Approach 2:
The fluoride ion source is extracted from the bulk paste matrix and incorporated into a separate fibrous composition. This extraction removes fluoride from the reactive aqueous environment where it would otherwise interact with calcium ions and other components, preserving its bioavailability while maintaining its anticaries function.
2Reliability
If fluoride ion sources are added to dentifrice compositions, then fluoride ions can interact with hydroxyapatite to produce fluorohydroxyapatite and strengthen dental enamel, but hydrolysis and oxidation of fluoride compounds in the aqueous phase reduce fluoride availability over time
Solution Approach 1:
The composition is segmented into fibrous and non-fibrous phases, with fluoride placed in the fibrous phase. This segmentation isolates fluoride from the aqueous environment that causes hydrolysis and oxidation during storage, extending its stability while preserving its ability to strengthen enamel upon application.
Solution Approach 2:
The fibrous composition provides a protected, low-reactivity environment for the fluoride ion source during storage. This inert-like environment minimizes exposure to moisture and oxygen that would otherwise cause hydrolysis and oxidation, maintaining fluoride stability until application.
3Speed
If fluoride ions are released rapidly into the oral cavity, then fluoride delivery and dispersal are enhanced for immediate anticaries benefits, but reactivity with other dentifrice components during storage reduces the amount of fluoride available for release
Solution Approach 1:
By segmenting the composition into separate fibrous and non-fibrous phases, the invention prevents premature reaction between fluoride and other components during storage. This ensures that the maximum amount of fluoride remains available for rapid release into the oral cavity when needed, without being consumed by unwanted reactions.
Solution Approach 2:
The fluoride ion source is pre-positioned in the fibrous composition in a stable, reactive state. This preliminary arrangement ensures that when the dentifrice is applied, fluoride is immediately available for rapid release and uptake by enamel, without having been depleted by storage-related reactions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach maintains fluoride bioavailability and efficacy by reducing reactivity, achieving a salivary fluoride pharmacokinetic area under the curve (pK AUC) that is at least 60% of a reference toothpaste, with improved fluoride delivery and anticaries benefits.
Implementation Method 1
The interaction of fluoride with the mineral component of teeth (known as hydroxyapatite or HAP) produces a fluorohydroxyapatite (FAP) mineral, through the substitution of OH− in HAP with F−
Implementation Method 2
The incorporation of fluoride into the dental enamel as FAP results in increased hydrogen bonding, a denser crystal lattice, and an overall decrease in the solubility of dental enamel
Implementation Method 3
The use of nonwoven webs to physically separate fluoride ions from other reactive components, such as calcium ions, in discrete phases within the oral care composition, ensuring minimal reactivity and enhanced fluoride uptake
Data Source
AI summary
Oral care compositions and/or unit-dose oral care compositions with a fluoride ion source. Oral care compositions and/or unit-dose oral care compositions with a high average fluoride ion uptake. Oral care compositions with one or more web forming materials, a calcium ion source, and a fluoride ion source with a high average fluoride uptake.