Fluoride Varnish Dissolved Inorganic Source

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Solution Overview

Problem

Current fluoride varnishes for dental applications face issues such as delayed fluoride release, high viscosity leading to thick films, visibility, potential for fluorosis, and allergic reactions due to natural resins, and unpleasant solvents, which hinder effective and comfortable treatment.

Innovation Solution

A fluoride-containing varnish composition with 25-87.5% organic solvent, 2-50% water, 5-50% water-insoluble film former, 0.5-10% dissolved inorganic fluoride source, and 5-25% plasticizer, allowing for rapid fluoride release and absorption by tooth enamel, forming a colorless, clear film with low viscosity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If suspended fluoride is used in varnish, then fluoride can be delivered to tooth surface, but fluoride release is delayed due to dissolution time required

Engineering Contradiction:

Improvefluoride deliveryVSAvoidfluoride release time

Core Design Contradiction:

Quantity of substanceVSLoss of time

Solution Approach 1:

The patent changes the physical state of fluoride from suspended particles to dissolved form in the varnish composition. This parameter change eliminates the dissolution step required for suspended fluoride, enabling immediate fluoride release upon application to the tooth surface while maintaining adequate fluoride delivery quantity.

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If high concentration of sodium fluoride is used, then adequate fluoridation is achieved, but risk of fluorosis increases

Engineering Contradiction:

Improvefluoride concentrationVSAvoidfluorosis risk

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent uses an organic solvent as an intermediary medium to deliver fluoride to the tooth surface. The organic solvent allows for lower fluoride concentration in the varnish formulation while achieving adequate fluoridation效果, thereby reducing fluorosis risk associated with high concentration sodium fluoride.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stability of the object's composition

If natural resins are used as film former, then film formation is achieved, but allergic reactions and asthma can be triggered

Engineering Contradiction:

Improvefilm formationVSAvoidallergic reactions

Core Design Contradiction:

Stability of the object's compositionVSObject-generated harmful factors

Solution Approach 1:

The patent extracts and removes natural resins from the varnish composition entirely, replacing them with synthetic film-forming polymers. This elimination of natural resin components prevents allergic reactions and asthma triggers while maintaining the essential film formation capability on the tooth surface.

Inventive Principle:

Principle #2Taking out (Extraction)

4Quantity of substance

If suspended fluoride particles are used, then fluoride source is provided, but particles settle during storage requiring homogenization

Engineering Contradiction:

Improvefluoride sourceVSAvoidstorage and application

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

The patent changes fluoride from suspended particulate form to dissolved molecular form in the organic solvent. This parameter change eliminates particle settling during storage, eliminating the need for homogenization before application, while maintaining adequate fluoride source availability.

Inventive Principle:

Principle #35Parameter changes

5Quantity of substance

If thick paint films are applied, then adequate fluoride coverage is achieved, but patient comfort is reduced due to visibility and disturbance

Engineering Contradiction:

Improvefluoride coverageVSAvoidpatient comfort

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

The patent uses organic solvent as a mediator that enables thin film formation while maintaining adequate fluoride delivery. The organic solvent provides effective fluoride transport in reduced quantities, allowing thin transparent films that improve patient comfort while achieving sufficient fluoridation coverage.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The varnish achieves high fluoride concentration on and in the enamel quickly, providing effective fluoridation and remineralization with reduced risk of fluorosis and allergic reactions, and improved patient comfort.

Implementation Method 1

0.5-10% inorganic source of fluoride in dissolved form

Methodology Applied

Scientific EffectDissolution:

Implementation Method 2

rapid fluoride release and absorption by tooth enamel

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 3

25-87.5% by weight organic solvent, 2-50% by weight Water

Methodology Applied

Scientific EffectSolvation: Solvation

Implementation Method 4

5-50% water-insoluble film former, forming a colorless, clear film

Methodology Applied

Scientific EffectFilm formation:

Data Source

PatentEP2705825B1Varnish containing fluoride for application to the surface of teeth

Publication Date: 2018.10.31 IVOCLAR VIVADENT AG

Figure 1

AI summary

Fluoride-containing varnish comprises 25-87.5 wt.% of an organic solvent, 2-50 wt.% of water, 5-50 wt.% of a water-insoluble film-forming agent, and 0.5-10 wt.% of an inorganic fluoride source in a dissolved form. ACTIVITY : Antibacterial. MECHANISM OF ACTION : None given.