Fluorinated Silane Coated Glass Container for Low Friction and Particulate Control
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Solution Overview
Problem
Pharmaceutical packaging, such as syringes and vials, face challenges with high friction properties and particulate emission, which can contaminate sensitive drug formulations, especially protein-based drugs, and existing solutions like fluorinated coatings have complexity and stability issues.
Innovation Solution
A container with a silicon oxide inner surface modified using a fluorine-containing alkoxysilane compound, chemically bonded via Si—O—Si bonds, which reduces particulate emission and improves friction properties while being stable and cost-effective, eliminating the need for silicone oils.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If silicone oil is applied to reduce friction, then sliding properties are improved, but particulate emission increases and contamination occurs
Solution Approach 1:
The patent removes silicone oil entirely from the system and replaces it with a fluorinated chemical compound coating. This extraction of the harmful substance (silicone oil) eliminates the source of particulate emission while maintaining lubrication through a different mechanism - the fluorinated coating provides low friction through its chemical structure and surface properties rather than through oil lubrication.
Solution Approach 2:
The patent changes the fundamental parameter of the lubricating substance from organic silicone-based oil to inorganic fluorinated chemical compound. This parameter change transforms the lubrication mechanism from oil-film lubrication to surface-coating lubrication, which does not migrate or emit particles into the pharmaceutical contents.
2Ease of operation
If perfluoropolyether lubricating oil is applied to reduce friction, then sliding properties are improved, but the process complexity increases and free oil can migrate into the drug solution
Solution Approach 1:
The fluorinated chemical compound is applied as a coating in advance and cured to form a stable, cross-linked layer on the inner surface. This preliminary action creates a permanent surface modification that provides lubrication without requiring subsequent application of free oil, eliminating migration issues and simplifying the overall process compared to plasma curing of PFPE.
3Object-generated harmful factors
If a second polymeric layer is applied over silicone to reduce particles, then particulate emission is reduced, but silicone oil can still migrate into the product under stress
Solution Approach 1:
Instead of layering a second coating over silicone oil, the patent extracts silicone oil completely from the system and uses only the fluorinated chemical compound coating. This eliminates the risk of silicone migration entirely, as there is no silicone present in the container system to migrate under mechanical or thermal stress.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution significantly reduces particulate emission and friction, maintaining stability during long-term storage, and is free from silicone oils, minimizing contamination and protein aggregation, thus enhancing the safety and efficacy of pharmaceutical formulations.
Implementation Method 1
the silicon oxide containing inner surface is modified with a fluorine containing compound, at least partially, wherein the fluorine containing compound is chemically bonded to the silicon oxide of the container body via at least one Si—O—Si bond
Implementation Method 2
high demands are placed on the friction properties of the inner surface of the packaging
Implementation Method 3
as few particles or particle-forming substances or migratable lubricating oils as possible should be released from the inner surface of the packaging into the pharmaceutical contents
Data Source
AI summary
The invention relates to a container comprising a container body having an outer surface and an inner surface, whereinthe inner surface contains silicon oxide; andthe silicon oxide containing inner surface is at least partially modified with a fluorine containing compound, wherein the fluorine containing compound is chemically bonded to the silicon oxide of the container body via at least one Si—O—Si bond.