Fluoroscopy Apparatus Defocus Reference Image Correction
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Solution Overview
Problem
Fluoroscopy apparatuses struggle to correct for variations in fluorescence intensity due to angle and distance of excitation light, as existing methods cannot quantitatively correct the entire image without deteriorating image quality due to unwanted information in reference images.
Innovation Solution
A fluoroscopy apparatus that acquires a fluorescence image and an out-of-focus reference image, allowing for correction of fluorescence intensity variations by dividing the fluorescence image by the reference image, thereby reducing unwanted information and improving image quality.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If correction is performed using a reference image containing surface condition information, then fluorescence intensity variations can be corrected, but image quality deteriorates due to unwanted information from edges and blood vessel structures
Solution Approach 1:
The patent extracts only the necessary distance and angle information from the reference image by performing defocus processing. This separates the useful correction data (intensity variations due to illumination geometry) from the unwanted information (surface features like edges and blood vessels), allowing correction without contaminating the fluorescence image with spurious structural details
Solution Approach 2:
The patent changes the focus parameter of the reference image by introducing defocus processing. By adjusting the focal position away from the observation target, the reference image loses high-frequency surface detail information while retaining the low-frequency intensity variation pattern caused by illumination angle and distance, thus providing clean correction data
2Measurement precision
If a sharp reference image is used for correction, then distance and angle information is preserved, but surface condition information contaminates the corrected fluorescence image
Solution Approach 1:
The patent extracts only the necessary distance and angle information from the reference image by performing defocus processing. This separates the useful correction data (intensity variations due to illumination geometry) from the unwanted information (surface features like edges and blood vessels), allowing correction without contaminating the fluorescence image with spurious structural details
Solution Approach 2:
The patent changes the focus parameter of the reference image by introducing defocus processing. By adjusting the focal position away from the observation target, the reference image loses high-frequency surface detail information while retaining the low-frequency intensity variation pattern caused by illumination angle and distance, thus providing clean correction data
3Manufacturing precision
If quantitative correction over the entire image is performed, then fluorescence intensity uniformity is improved, but image quality deteriorates due to information in the reference image
Solution Approach 1:
The patent extracts only the necessary distance and angle information from the reference image by performing defocus processing. This separates the useful correction data (intensity variations due to illumination geometry) from the unwanted information (surface features like edges and blood vessels), allowing correction without contaminating the fluorescence image with spurious structural details
Solution Approach 2:
The patent changes the focus parameter of the reference image by introducing defocus processing. By adjusting the focal position away from the observation target, the reference image loses high-frequency surface detail information while retaining the low-frequency intensity variation pattern caused by illumination angle and distance, thus providing clean correction data
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables the acquisition of high-precision fluorescence images with quantitative intensity information, independent of the angle and distance of the excitation light, without requiring complex image processing or special optical systems.
Implementation Method 1
a fluorescent substance contained in the observation target is excited, generating fluorescence
Data Source
AI summary
Unwanted information contained in a reference image is reduced, thus acquiring a fluorescence image having quantitative intensity information, regardless of the angle and distance of excitation light. The invention provides a fluoroscopy apparatus including an illumination portion that irradiates an observation target with illumination light containing excitation light; a first image-acquisition section that acquires a fluorescence image in a prescribed observation region of the observation target; a second image-acquisition section that acquires an out-of-focus reference image of the observation target in the observation region; and an image correction section that corrects the fluorescence image acquired by the first image-acquisition section using the reference image acquired by the second image-acquisition section.