Flupyrimin nAChR Modulation for Resistant Corn Pest Control
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Solution Overview
Problem
Existing methods for controlling corn pests, particularly Spodoptera frugiperda, Diabrotica speciosa, and Dalbulus maidis, face challenges due to insecticide-resistant pest populations and inconsistent application technology, leading to reduced crop yields and economic viability.
Innovation Solution
The use of flupyrimin, a pyridylidene class insecticide with nicotinic acetylcholine receptor (nAChR) competitive modulatory activity, applied at lower doses to control and prevent infestation by corn pests, including resistant strains, through direct or indirect contact with plants, seeds, and their environment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional insecticides are applied to control corn pests, then pest control efficacy is initially good, but pest resistance develops leading to reduced efficacy over time
Solution Approach 1:
The patent introduces a new chemical compound (flupyrimin) with distinct molecular structure and mode of action parameters compared to conventional insecticides. This parameter change in chemical structure enables effective control of pests that have developed resistance to existing insecticide classes, thereby resolving the efficacy-resistance contradiction
Solution Approach 2:
The patent combines flupyrimin with other insecticidal compounds or formulations to create composite pest control solutions. This composite approach provides multiple modes of action simultaneously, preventing resistance development while maintaining high control efficacy
2Reliability
If higher doses of insecticides are applied to ensure complete pest control, then pest control efficacy improves, but environmental toxicity and ecological impact increase
Solution Approach 1:
Flupyrimin exhibits high potency at low application rates due to its specific binding affinity to nicotinic acetylcholine receptors in pests. This parameter optimization allows achieving 95% or greater control efficacy while maintaining lower field application rates, thereby reducing environmental exposure and toxicity concerns
Solution Approach 2:
The patent employs a new chemical entity (flupyrimin) that degrades relatively quickly in the environment compared to persistent conventional insecticides. This short-lived nature ensures rapid breakdown after pest control is achieved, minimizing long-term environmental accumulation and toxicity while maintaining high short-term efficacy
3Reliability
If insecticide application is increased to overcome resistant pest populations, then pest control coverage improves, but application cost and environmental burden increase
Solution Approach 1:
Flupyrimin's optimized pharmacokinetic parameters including high target binding affinity and selective toxicity enable effective control at reduced application rates. The compound achieves broad-spectrum coverage against multiple pest species while requiring lower field application quantities compared to conventional insecticides
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Flupyrimin effectively reduces pest damage, increases crop yield by at least 5%, and ensures eco-friendliness by maintaining plant health without significant toxicity, offering broad-spectrum control against various insect species.
Implementation Method 1
Flupyrimin [N-[(E)-1-(6-chloro-3-pyridinylmethyl)pyridin-2 (1H)-ylidene]-2,2,2-trifluoroacetamide], a nicotinic acetylcholine receptor (nAChR) competitive modulator
Data Source
AI summary
The present invention discloses a method for controlling corn pests. More particularly, the present invention relates to a method of controlling infestation of corn pests and a composition comprising pyridylidene class of insecticide for controlling the corn pests.