Fluxapyroxad and Folpet Mixture for Ramularia Control

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Solution Overview

Problem

Current fungicides, particularly SDHI fungicides, face challenges in controlling Septoria tritici blotch and Ramularia fungal diseases due to rapid resistance development, requiring a combination that offers broader disease control and reduced dosage requirements.

Innovation Solution

A fungicidal combination of fluxapyroxad and folpet, which provides synergistic activity and delays resistance development, allowing for improved control of Ramularia fungi with reduced active compound amounts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If SDHI fungicides are used to control fungal diseases, then disease control efficacy is improved, but resistance development occurs rapidly

Engineering Contradiction:

Improvedisease control efficacyVSAvoidresistance development time

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent combines fluxapyroxad (SDHI fungicide) with folpet (multisite contact fungicide) to create a mixed fungicidal composition. This combination leverages the high efficacy of SDHI while using folpet's multisite mechanism to delay resistance development, thus resolving the contradiction between maintaining disease control efficacy and preventing rapid resistance.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite fungicidal system by formulating fluxapyroxad and folpet together in specific ratios. This composite approach allows the two fungicides with different modes of action to work synergistically, maintaining effective disease control while the multisite contact activity of folpet prevents the rapid resistance that occurs with SDHI alone.

Inventive Principle:

Principle #40Composite materials

2Reliability

If higher dosages of fungicides are applied to control resistance, then disease control is improved, but crop tolerance decreases and treatment cost increases

Engineering Contradiction:

Improvedisease controlVSAvoidcrop tolerance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

By combining fluxapyroxad and folpet in a mixed composition, the patent achieves synergistic or additive disease control effects at lower total dosages. The folpet component provides contact protection that complements fluxapyroxad's systemic activity, allowing effective control without the need for high dosages that would harm crop tolerance or increase costs.

Inventive Principle:

Principle #5Merging (Combining)

3Adaptability or versatility

If triazoles or strobilurins are mixed with SDHI fungicides, then disease control spectrum is broadened, but resistance development is not sufficiently prevented

Engineering Contradiction:

Improvedisease control spectrumVSAvoidresistance prevention

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent changes the key parameter of mode of action by selecting folpet, a multisite contact fungicide, instead of triazoles or strobilurins. This parameter change is crucial because multisite contact activity fundamentally differs from single-site systemic fungicides, providing inherent resistance prevention while maintaining broad disease control spectrum when combined with fluxapyroxad.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentEP3905883B1Fungicidal mixture

Publication Date: 2024.03.27 ADAMA MAKHTESHIM LTD

AI summary

The present invention relates to fungicidal mixtures comprising a) a succinate dehydrogenase inhibitor fungicide; and b) folpet.