Pharmaceutical-Free Foamable Composition for Skin Treatment
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Solution Overview
Problem
Existing foamable compositions for skin treatments require pharmaceutically active ingredients, which can cause unwanted side effects and have limitations such as low solubility, necessitating the development of a composition free from these agents.
Innovation Solution
A foamable composition comprising emollients, stabilizers, preservatives, emulsifiers, foam stabilizers, and moisturizers, along with a propellant, specifically using caprylic/capric triglyceride, cetostearyl alcohol, benzoic acid, PEG-40 stearate, methylcellulose, xanthan gum, dimethyl isosorbide, and propylene glycol, that is essentially free of pharmaceutically active ingredients, for treating skin conditions like rosacea, acne, and dermatitis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pharmaceutically active ingredients are used in foamable compositions, then therapeutic efficacy is improved, but unwanted side effects and adverse events occur
Solution Approach 1:
The patent removes pharmaceutically active ingredients from the foamable composition entirely, extracting the harmful therapeutic agents while retaining the beneficial foam delivery system. The composition now contains only emollients, stabilizers, preservatives, emulsifiers, foam stabilizers, moisturizers, and propellants, eliminating side effects while maintaining skin treatment capabilities through the foam vehicle itself.
2Reliability
If pharmaceutically active ingredients are used to treat skin conditions, then treatment effectiveness is improved, but solubility limitations arise
Solution Approach 1:
The patent eliminates the solubility problem by removing pharmaceutically active ingredients that require dissolution. Without these ingredients, the composition avoids all solubility limitations while maintaining treatment effectiveness through the foam delivery system and skin-care active ingredients that do not suffer from solubility issues.
3Reliability
If a comprehensive formulation with multiple ingredients is used, then therapeutic benefits are improved, but composition complexity increases
Solution Approach 1:
The patent simplifies the composition by extracting and removing pharmaceutically active ingredients, reducing formulation complexity while maintaining therapeutic benefits through the foam vehicle and skin-care ingredients. The simplified formulation contains fewer components that are easier to manufacture and regulate.
Solution Approach 2:
The foamable composition serves multiple functions simultaneously: it provides skin moisturization through emollients and moisturizers, ensures stability with stabilizers, prevents contamination with preservatives, maintains foam structure with foam stabilizers, and delivers all benefits through a single propellant-driven foam delivery system, eliminating the need for separate therapeutic agents.
Data Source
AI summary
The present invention related to the use of a pharmaceutical composition which is essentially free of pharmaceutically active ingredients for the treatment of human skin, especially in the treatment of rosacea, acne, atopic dermatitis, contact dermatitis, perioral dermatitis, psoriasis or neurodermitis, as well as for prophylactic and/or cosmetic purposes.