Foamable Iodine Composition for Painless Skin Application

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Solution Overview

Problem

Conventional iodine compositions for topical treatment are limited to liquid or semi-liquid forms, making it difficult and painful to apply over large areas, especially on sensitive skin or open wounds, as they require rubbing and can cause irritation.

Innovation Solution

A foamable composition comprising iodine, water, a foam adjuvant, a surface-active agent, and a gelling agent, with specific gravity ranging from 0.02 to 0.35 g/ml, which forms a breakable or collapsible foam for easy application and high iodine availability on the skin surface.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If conventional liquid or semi-liquid iodine compositions are used, then the iodine can be delivered to the skin surface, but the application becomes difficult and painful over large areas, especially on sensitive skin or open wounds

Engineering Contradiction:
Improveease of applicationVSAvoidskin irritation
Core Design Contradiction:
Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent transforms the physical state of the iodine composition from liquid or semi-liquid to foam. This parameter change in physical form allows the composition to be applied without rubbing, eliminating skin irritation while maintaining effective iodine delivery to the skin surface. The foam structure provides a gentle, non-abrasive application method suitable for sensitive skin and open wounds.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention utilizes phase transition by converting the iodine composition into a foam state. This phase change from conventional liquid/semi-liquid form to foam creates a product that can be applied painlessly over large areas without causing skin irritation, while still delivering therapeutic levels of iodine to the treatment area.

Inventive Principle:
Principle #36Phase transitions

2Stability of the object's composition

If liquid or semi-liquid iodine compositions are used, then the formulation can maintain stability, but the specific gravity ranges from 0.7-1.1 making it difficult to apply over large skin areas

Engineering Contradiction:
Improveformulation stabilityVSAvoidease of application
Core Design Contradiction:
Stability of the object's compositionVSEase of operation

Solution Approach 1:

The patent changes the physical parameter of the composition from liquid/semi-liquid to foam, which fundamentally alters the application characteristics. The foam form maintains formulation stability while dramatically improving ease of application over large skin areas, as foam can be gently applied without the need for rubbing or spreading that characterizes liquid formulations.

Inventive Principle:
Principle #35Parameter changes

3Quantity of substance

If iodine is dissolved in ethanol to achieve solubility, then iodine can be properly dissolved, but it precipitates in the presence of water

Engineering Contradiction:
Improveiodine solubilityVSAvoidcomposition stability
Core Design Contradiction:
Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent employs tetraglycol as an intermediary substance that facilitates iodine dissolution and maintains stability in the presence of water. Tetraglycol acts as a mediator between iodine and water, preventing precipitation while ensuring proper dissolution and sustained antiseptic effect, thus resolving the contradiction between solubility and stability.

Inventive Principle:
Principle #24Intermediary (Mediator)

4Reliability

If conventional iodine formulations are used, then they can provide antiseptic activity, but they require rubbing application which is difficult and painful on sensitive areas

Engineering Contradiction:
Improveantiseptic efficacyVSAvoidapplication method
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The invention changes the physical state parameter from liquid/semi-liquid to foam, which eliminates the need for rubbing application. The foam structure allows for gentle, painless application over sensitive areas and open wounds while maintaining reliable antiseptic efficacy through controlled iodine release and sustained skin contact.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The foamable composition allows for easy and painless application over large areas, providing effective treatment for various skin conditions, including burns, infections, and dermatological disorders, without causing irritation, and is suitable for both human and veterinary use.

Implementation Method 1

a foamable composition comprising iodine, water, a foam adjuvant, a surface-active agent, and a gelling agent, with specific gravity ranging from 0.02 to 0.35 g/ml, which forms a breakable or collapsible foam

Methodology Applied
Scientific EffectFoam: Foam

Implementation Method 2

a surface-active agent

Methodology Applied
Scientific EffectSurface tension reduction: Surfactant

Implementation Method 3

Iodine has a powerful bactericidal and fungicidal action and is also active against viruses

Methodology Applied
Scientific EffectOxidation: Oxidation

Implementation Method 4

molecular iodine and tetraglycol (TG) that facilitates the dissolution of iodine, enhances its antiseptic effect, and remains stable in the presence of water

Methodology Applied
Scientific EffectSolvation: Solvation

Implementation Method 5

acetalized polyvinyl alcohol complexed with iodine, which releases free iodine in the presence of water

Methodology Applied
Scientific EffectComplex dissociation:

Data Source

PatentUS7575739B2Foamable iodine composition
Publication Date: 2009.08.18 VYNE THERAPEUTICS INC
  • US7575739B2 patent drawing

AI summary

The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.