Folic Acid Gingerol Formulation for Nausea Suppression
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Solution Overview
Problem
Current treatments for morning sickness and folic acid deficiency often cause gastric distress and nausea, necessitating the development of improved formulations that address these side effects while effectively providing folic acid.
Innovation Solution
Formulations combining effective amounts of folic acid with gingerol compositions, such as 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, and 10-shogaol, in various dosage forms like tablets, gel caps, and oral solutions, to suppress nausea and promote hematopoiesis, using an oil base or supercritical fluid extraction for enhanced bioavailability and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If folic acid is administered to treat folic acid deficiency, then the deficiency is corrected, but nausea and gastric distress occur
Solution Approach 1:
The patent introduces gingerol as an intermediary substance that mediates between folic acid and the gastrointestinal system. Gingerol acts as a protective agent that reduces the harmful effects of folic acid on the stomach while allowing the beneficial effects of folic acid supplementation to proceed. This is achieved by combining folic acid with gingerol in a single formulation, where gingerol serves as the mediator that suppresses nausea and gastric distress caused by folic acid administration.
2Reliability
If conventional formulations are used to provide folic acid, then the treatment is effective, but patient tolerance is poor due to side effects
Solution Approach 1:
The patent creates a composite formulation by combining folic acid with gingerol in specific ratios. This composite material approach integrates two substances with different functions: folic acid provides the therapeutic effect for deficiency correction, while gingerol provides the gastroprotective effect that improves patient tolerance. The composite formulation is prepared by mixing folic acid with gingerol extract or gingerol compounds, creating a unified dosage form that delivers both benefits simultaneously.
Data Source
AI summary
Embodiments of the present invention are directed to formulations and methods of treating folic acid deficiency and morning sickness. The dosage form has an effective amount, of a folic add with an effective amount of a gingerol composition to suppress nausea and/or gastric distress and to promote hematopoiesis.