Folic Acid Microsphere Gel for Drug-Induced Gingival Overgrowth
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Solution Overview
Problem
Drug-induced gingival overgrowth (DIGO) is a common side effect of medications like anticonvulsants, immunomodulators, and antihypertensives, leading to esthetic, functional, and periodontal complications, with existing treatments being inadequate.
Innovation Solution
Compositions comprising a polymeric gel with a plurality of microspheres that encapsulate folic acid are used to treat DIGO and methods of using the devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for drug-induced gingival overgrowth are used, then the condition can be managed to some extent, but the treatments are inadequate and do not provide sufficient therapeutic effect
Solution Approach 1:
The patent introduces folic acid as an intermediary substance that mediates the treatment of DIGO. Folic acid acts as a mediator between the drug-induced pathological process and the therapeutic intervention, specifically targeting the folate metabolism pathway that is dysregulated in DIGO. This intermediary approach provides a more adequate and effective treatment compared to conventional methods.
2Productivity
If existing treatment methods are applied, then some management of gingival overgrowth is achieved, but the treatments lack sufficient efficacy and fail to address the underlying mechanisms
Solution Approach 1:
The patent changes the therapeutic parameter by targeting folate metabolism, specifically through the use of folic acid supplementation. This parameter change addresses the underlying biochemical mechanism of DIGO related to drug-induced folate deficiency, thereby improving treatment efficacy without requiring complex intervention systems.
Data Source
AI summary
Disclosed are gel compositions containing microspheres that encapsulate folic acid and optionally one or more drugs, one or more peptides, one or more growth factors, one or more nucleic acids, or the like, or combinations thereof. The compositions may be in or applied to a device, such as, for example, a dental prosthetic. The composition may be used to treat an individual afflicted with or suspected of having drug-induced gingival overgrowth (DIGO). The composition may be applied directly to the individual or applied through a device, such as, for example, a dental prosthetic. Also described is a method of method of making the composition, a method of making a device, and methods for using the composition.