Noninvasive Glucose Analyzer Using Force-Optic Tissue Modification

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Solution Overview

Problem

There is a need for a noninvasive method to determine glucose concentration in the human body effectively, as existing technologies have limitations in accurately measuring glucose levels without invasive procedures.

Innovation Solution

A noninvasive glucose concentration analyzer system using applied force-optic technology, which applies physical forces to alter tissue properties, allowing spectrometers to measure glucose levels through changes in absorbance and scattering of photons in the visible and near-infrared regions, utilizing multiple spectrometer units and a controller to process signals for accurate glucose concentration determination.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If noninvasive optical methods are used to measure glucose concentration, then patient comfort and safety are improved, but measurement precision deteriorates due to interference from tissue properties

Engineering Contradiction:
ImproveinvasivenessVSAvoidglucose concentration measurement accuracy
Core Design Contradiction:
Object-affected harmful factorsVSMeasurement precision

Solution Approach 1:

The patent applies force to the tissue to change its physical parameters (density, refractive index, molecular packing) temporarily, which modifies the optical properties and enhances the glucose-specific spectral signal. This allows noninvasive measurement while improving precision by dynamically adjusting tissue parameters to favor glucose detection.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The applied force acts as an intermediary that modifies the tissue state to improve the interaction between light and glucose molecules. By introducing this mechanical intermediary, the system overcomes the limitation of direct optical measurement through tissue, enabling accurate noninvasive glucose concentration determination.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If multiple spectrometer units are used to improve measurement accuracy, then measurement precision is improved, but device complexity increases

Engineering Contradiction:
Improveglucose concentration measurement accuracyVSAvoidanalyzer system structure
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system divides the measurement task into multiple spectral regions by using multiple spectrometer units, each optimized for specific wavelength ranges. This segmentation allows simultaneous collection of complementary spectral information, improving glucose measurement precision while distributing the complexity across modular components.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent extends the measurement from a single spectral dimension to multiple spectral dimensions by employing multiple spectrometer units covering different wavelength ranges. This multi-dimensional spectral analysis provides redundant and complementary information, enhancing measurement accuracy despite increased system complexity.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables noninvasive and accurate measurement of glucose levels by altering tissue properties with applied forces, enhancing the detection of glucose concentration through changes in absorbance and scattering, providing a reliable and minimally invasive method for glucose monitoring.

Implementation Method 1

measure glucose levels through changes in absorbance and scattering of photons

Methodology Applied
Scientific EffectAbsorbance: Absorption (EM radiation)

Implementation Method 2

measure glucose levels through changes in absorbance and scattering of photons

Methodology Applied
Scientific EffectScattering: Scattering

Implementation Method 3

applies physical forces to alter tissue properties, allowing spectrometers to measure glucose levels through changes in absorbance and scattering

Methodology Applied
Scientific EffectForce-induced tissue property change: Deformation

Data Source

PatentUS11633130B2Multiple sensor glucose concentration determination analyzer apparatus and method of use thereof
Publication Date: 2023.04.25 LIFE PLUS INC
  • US11633130B2 patent drawing
  • US11633130B2 patent drawing
  • US11633130B2 patent drawing

AI summary

The invention comprises a method and apparatus for noninvasively determining state of a person, comprising the steps of: providing an analyzer comprising a first and second spectrometer unit and a main controller subsystem; replaceably attaching the first spectrometer unit to the person at a first illumination zone; the first spectrometer unit delivering first photons, from first illumination optics, along a first mean z-axis optical path normal to a first x/y-plane tangentially contacting the first illumination zone of the person; replaceably attaching a second spectrometer unit to the person at a second illumination zone; the second spectrometer delivering second photons, from second illumination optics, along a second mean z-axis optical path perpendicular to a second x/y-plane tangentially contacting the second illumination zone of the skin, the first x/y-plane noncoplanar with the second x/y-plane; and the main controller processing detected signals to generate at least one measure of state of the person.