Formula I Aldehydes Replace Lyral in Perfume Formulations
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Solution Overview
Problem
The European Scientific Committee for Consumer Safety has raised allergenic concerns regarding Lyral™, a widely used perfume ingredient with a muguet (lily of the valley) odor, which may face regulatory action, necessitating the development of alternative compounds that replicate its odor characteristics and performance without the associated risks.
Innovation Solution
Development of novel compounds, specifically represented by formula I, which possess muguet odor characteristics similar to Lyral™, allowing for their use as direct replacements in perfume compositions, including 9-hydroxy-4,6,9-trimethyldec-4-enal, 9-hydroxy-6,9-dimethyldec-4-enal, and other related aldehydes, that can be used in pure or enriched isomeric forms or as isomeric mixtures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If Lyral™ is used as a perfume ingredient, then muguet odor characteristics are achieved, but allergenic concerns arise
Solution Approach 1:
The patent creates a copy of Lyral™'s odor characteristics using structurally similar compounds (9-hydroxy-4,6,9-trimethyldec-4-enal and related aldehydes) that replicate the desired muguet scent profile without containing the actual Lyral™ molecule, thereby eliminating allergenic risks while maintaining olfactory performance
Solution Approach 2:
The invention modifies the chemical structure parameters of Lyral™ by changing the hydroxyl group position and carbon chain configuration to create new compounds with formula I, which maintain the essential odor characteristics while removing the allergenic properties associated with the original structure
2Object-affected harmful factors
If alternative compounds are developed to replace Lyral™, then allergenic risks are reduced, but odor performance may be compromised
Solution Approach 1:
The patent systematically varies structural parameters (hydroxyl position, methyl group placement, carbon chain length) to optimize both safety and olfactory performance, demonstrating that compounds of formula I achieve reliable muguet odor characteristics comparable to or exceeding Lyral™ while maintaining allergenic safety
Solution Approach 2:
The invention employs composite approaches by using single compounds or mixtures of compounds with formula I that collectively deliver robust, long-lasting muguet odor performance, ensuring reliability through synergistic or additive olfactory effects while maintaining safety
3Device complexity
If single compound replacement is used, then formulation simplicity is improved, but cost-effectiveness must be maintained
Solution Approach 1:
The patent enables direct one-to-one replacement of Lyral™ with a single compound or defined mixture of compounds of formula I, simplifying formulation development and regulatory approval processes while maintaining cost-effectiveness through straightforward substitution without requiring complex multi-component systems
Data Source
AI summary
Said compounds are useful as perfume ingredients in personal care and household care products.