Formula I Anthelmintic Compounds for Resistant Parasites
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current anthelmintic agents face challenges due to evolutionary resistance by parasites, limited spectrum of activity, and the need for repeated treatments, necessitating the development of new compounds effective against a wide range of endoparasitic infections.
Innovation Solution
Development of compounds corresponding to Formula I, with specific substituents and linkers, which can be used as anthelmintic agents, including pharmaceutical compositions and methods for their administration to treat parasitic infections in animals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing anthelmintic agents are used to treat parasitic infections, then treatment effectiveness is maintained initially, but parasites develop evolutionary resistance over time rendering the drugs obsolete
Solution Approach 1:
The patent applies parameter changes by developing compounds with modified chemical structures (Formula I with various R1, R2, R3, R4, R5, R6 substituents) that alter the molecular parameters of anthelmintic agents. This structural modification enables the new compounds to maintain treatment effectiveness while overcoming evolutionary resistance that has rendered existing drugs obsolete.
Solution Approach 2:
The patent employs composite materials by creating anthelmintic compounds that combine multiple structural elements and functional groups in Formula I. These composite molecular structures integrate different chemical moieties (aromatic rings, heteroatoms, substituent groups) to achieve broad-spectrum activity and sustained efficacy against resistant parasites.
2Adaptability or versatility
If existing anthelmintic drugs are used, then some parasitic infections can be treated, but the spectrum of activity is limited and repeated treatments are needed
Solution Approach 1:
The patent implements universality by designing anthelmintic compounds of Formula I with versatile structural features that enable broad-spectrum activity against multiple parasite types (nematodes, cestodes, trematodes). The compounds are engineered to perform multiple functions: treating various parasitic infections simultaneously and providing prolonged action that reduces the need for repeated administrations.
Data Source
AI summary
This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration ofthe compounds and salts to animals in need of the treatments.