Nanoemulsion of Forsythia and Bupleuri Oils for Stability
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Solution Overview
Problem
The existing mixture of Forsythia suspensa oil and Radix bupleuri oil lacks a nanoemulsion preparation, resulting in low stability, low bioavailability, and insolubility in water, which affects their therapeutic efficacy due to volatility and small toxic side effects.
Innovation Solution
A compound Forsythia suspensa-Radix bupleuri oil nanoemulsion preparation is developed, comprising specific percentages of surfactant, co-surfactant, oil, Forsythia suspensa oil, Radix bupleuri oil, vitamin C, and vitamin B1, with Tween-80 as the surfactant and ethanol as the co-surfactant, forming a stable and transparent spray that enhances bioavailability and solubility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Forsythia suspensa oil and Radix bupleuri oil are used directly, then antipyretic and antibacterial effects are achieved, but water solubility is poor and stability is low
Solution Approach 1:
The patent transforms the physical state and solubility parameters of the medicinal oils by converting them into a nanoemulsion form. This involves changing the droplet size to nanometer scale and adjusting the interfacial properties through surfactant selection, thereby achieving water dispersibility while maintaining the original oil's stability and therapeutic properties.
Solution Approach 2:
The invention creates a composite nanoemulsion system combining hydrophobic medicinal oils (Forsythia suspensa oil and Radix bupleuri oil) with hydrophilic components (surfactants, co-surfactants, and water). This composite structure allows the incompatible phases to coexist stably, achieving both water solubility and oil stability simultaneously.
2Reliability
If Forsythia suspensa oil and Radix bupleuri oil are used directly, then therapeutic effects are achieved, but bioavailability is low due to volatility
Solution Approach 1:
The nanoemulsion droplets act as flexible protective shells around the volatile medicinal oils. The surfactant monolayer forms a thin film that encapsulates the oil core, preventing direct contact with the environment and reducing volatility-induced loss, thereby improving bioavailability while maintaining therapeutic effects.
3Manufacturing precision
If traditional mixture preparation is used, then simplicity is maintained, but quality uniformity and stability are poor
Solution Approach 1:
The patent employs preliminary action by pre-mixing the surfactant and co-surfactant to form a stable surfactant phase before adding the medicinal oils. This pre-preparation ensures consistent interfacial properties and facilitates uniform nanoemulsion formation, improving quality uniformity while keeping the overall process manageable.
Solution Approach 2:
The invention replaces complex mechanical mixing systems with a simplified emulsification approach using ultrasonic treatment or high-speed stirring combined with optimized surfactant selection. This substitution achieves uniform nanoemulsion distribution without requiring complex equipment, balancing manufacturing precision with process simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nanoemulsion preparation achieves high stability, improved bioavailability, and effective antipyretic, antibacterial, and virus-inhibiting effects, with enhanced solubility and ease of preparation, suitable for treating conditions like heat cold and upper respiratory tract infections.
Implementation Method 1
12.00%-28.00% of a surfactant, 15.00%-30.00% of a co-surfactant
Implementation Method 2
compound Forsythia suspensa-Radix bupleuri oil nanoemulsion preparation
Implementation Method 3
The mixture was subjected to ultrasonic wave treatment at 40 kHz and 300 W for 30 minutes
Implementation Method 4
0.01%-0.05% of vitamin C, 0.01 %-0.05% of vitamin B 1
Data Source
AI summary
A compound Forsythia suspensa-Radix bupleuri oil nanoemulsion preparation, having droplet size between 10 nm and 100 nm, and prepared from raw materials with the following percentages by weight: 12.00%-28.00% of a surfactant, 15.00%-30.00% of a co-surfactant, 3.00%-8.00% of oil, 0.10%-5.00% of Forsythia suspensa oil, 0.10%-5.00% of Radix bupleuri oil, 0.01%-0.05% of vitamin C, 0.01%-0.05% of vitamin B1 and 20.00%-68.40% of distilled water, and the total percentages by weight of all the raw materials is 100%.