Fractional Lobe Twin-Screw Granulator for Monomodal Particle Control

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Solution Overview

Problem

Current continuous twin-screw granulation processes result in bi-modal or tri-modal particle size distribution, irregular particle shapes, inadequate process control, and require post-processing drying steps, leading to unpredictable outcomes due to various process variables.

Innovation Solution

A fractional lobe processor with intermeshing screws and zones for intake, granulation, and drying, utilizing fractional lobe elements to achieve symmetrical particle shapes and controlled particle size distribution, eliminating the need for external drying.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional twin-screw granulation is used, then continuous processing is achieved, but bi-modal or tri-modal particle size distribution and irregular particle shapes result

Engineering Contradiction:
Improvecontinuous processingVSAvoidparticle size distribution
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The granulation process is segmented into distinct zones along the twin-screw processor: a feeding zone for material introduction, a granulation zone with specific screw elements for controlled granule formation, and a drying zone for moisture removal. This spatial segmentation allows each zone to optimize for its specific function, achieving continuous processing while producing uniform monomodal particle size distribution.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Different screw elements with specific geometries are used in different zones of the processor. The granulation zone employs elements designed for intimate mixing and granule formation, while the drying zone uses elements optimized for moisture removal. This local optimization of screw element geometry enables continuous processing with precise control over particle size distribution.

Inventive Principle:
Principle #3Local quality

2Productivity

If conventional twin-screw granulation is used, then processing continues without interruption, but inadequate process control and unpredictable outcomes occur

Engineering Contradiction:
Improvecontinuous operationVSAvoidprocess control
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The processor incorporates torque measurement and monitoring capabilities that provide real-time feedback on the granulation process. This feedback mechanism enables detection of process variations and adjustment of operating parameters to maintain consistent particle size distribution and granule quality throughout continuous operation, thereby improving process control and predictability.

Inventive Principle:
Principle #23Feedback

3Loss of substance

If external drying step is added, then moisture removal is achieved, but process complexity and post-processing requirements increase

Engineering Contradiction:
Improvemoisture removalVSAvoidprocess steps
Core Design Contradiction:
Loss of substanceVSDevice complexity

Solution Approach 1:

The drying function is merged with the granulation process by incorporating a drying zone directly within the twin-screw processor. This integration combines granule formation and moisture removal into a single continuous operation, eliminating the need for separate external drying equipment and post-processing steps, thereby reducing overall process complexity.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The twin-screw processor is designed to perform multiple functions within a single device: material feeding, granulation, and drying. This multi-functionality is achieved through the use of different screw elements in different zones, allowing the same machine to accomplish what would traditionally require multiple separate pieces of equipment.

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Manufacturing precision

If more screw elements are added to control process variables, then process control improves, but device complexity increases

Engineering Contradiction:
Improveparticle size controlVSAvoidscrew element configuration
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The screw elements are arranged in segmented zones along the processor length, with each zone containing elements optimized for its specific function. This segmentation provides systematic control over the granulation process without requiring excessive complexity, as each zone can be independently designed and adjusted for its particular purpose.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The processor produces granules with uniform particle size, improved flowability, compressibility, and strength, achieving desired attributes without external drying, and provides precise control over process conditions.

Implementation Method 1

a barrel with heating and cooling means

Methodology Applied
Scientific EffectHeating: Heating

Implementation Method 2

a barrel with heating and cooling means

Methodology Applied
Scientific EffectCooling: Cooling

Implementation Method 3

two parallel intersecting bores of equal diameter, wherein the centre distance between the two bores is lesser than the diameter of the bore

Methodology Applied
Scientific EffectShear stress: Shear Stress

Implementation Method 4

an optional, drying zone for drying the wet granules

Methodology Applied
Scientific EffectEvaporation: Evaporation

Data Source

PatentUS11247378B2Processor and a process for granulation of powders
Publication Date: 2022.02.15 STEERLIFE INDIA PTE LTD
  • US11247378B2 patent drawing
  • US11247378B2 patent drawing
  • US11247378B2 patent drawing

AI summary

A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.