Fractionated Ocular Dosing for Better Therapeutic Effect
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Solution Overview
Problem
Existing dose optimization methods for therapeutic agents do not account for the potential benefits of fractionating doses into multiple smaller fractions, leading to suboptimal therapeutic effects and side effects.
Innovation Solution
A method of delivering therapeutic agents in fractionated doses, split into two or more dose-fractions separated by short intervals, to enhance or alter biological effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single conventional dose is administered, then the total dose is delivered efficiently, but the therapeutic effect is suboptimal and side effects occur
Solution Approach 1:
The patent applies segmentation by dividing a single conventional dose into multiple smaller dose-fractions (e.g., 2-4 fractions) administered at short intervals (5-30 minutes apart). This segmentation allows the total dose to be delivered while improving therapeutic efficacy and reducing side effects through the fractionation effect, where each fraction re-sensitizes receptors between exposures
2Ease of operation
If dose timing is optimized at regular intervals, then dosing schedule is simple, but the potential benefits of fractionating doses are not accounted for
Solution Approach 1:
The patent implements periodic action through structured fractionated dosing schedules where multiple dose-fractions are administered at regular short intervals (e.g., every 5-30 minutes) within a dosing event, with subsequent dosing events occurring at standard intervals (e.g., every 4-6 hours). This maintains operational simplicity while incorporating the therapeutic benefits of fractionation
Data Source
AI summary
The efficacy of a dosing regimen can be altered, and preferably improved, by fractionating the doses. Here fractionating the doses can be regarded as taking a single conventional dose and splitting that dose into two or more dose-fractions delivered at relatively short time intervals, where the dose-fractions add up to the same total dose as the conventional dose. In cases where dose fractionation increases the therapeutic effect, this can result in a greater therapeutic effect from a smaller total dose when the doses are fractionated. This effect has been demonstrated in an ophthalmic application, but is expected to be more generally applicable.