Freeze-Dried Platelet Compositions for Rapid Hemostasis
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Solution Overview
Problem
Current compositions for treating wounds and promoting hemostasis are not effective enough, particularly in rapid and multi-setting applications, and there is a need for improved methods to stop blood loss and enhance tissue regeneration.
Innovation Solution
Development of freeze-dried platelet compositions that include platelets and microparticles, which can be rehydrated for use as injectable or topical treatments, incorporating saccharides and cryoprotectants to maintain clotting function and promote wound healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If platelet gel is used alone as a hemostasis agent, then the composition is simple and easy to apply, but it is not effective enough to stop bleeding rapidly
Solution Approach 1:
The patent combines platelet gel with microparticles in a single composition to achieve both simplicity of application and enhanced hemostatic effectiveness. The microparticles are incorporated into the platelet gel matrix, creating a composite hemostatic agent that leverages the adhesive properties of platelet gel while the microparticles provide additional pro-coagulant surfaces to accelerate clot formation and improve reliability.
2Productivity
If current hemostatic compositions are used, then they can be applied in various settings, but they do not accelerate clot formation rapidly enough
Solution Approach 1:
The patent changes the physical and chemical parameters of the hemostatic composition by incorporating microparticles with specific surface properties and pro-coagulant factors. These parameter changes enhance the thrombin-generating capacity of the composition, accelerating clot formation speed while maintaining reliable hemostatic performance across different application settings.
3Duration of action of stationary object
If platelets are stored for extended periods, then availability is improved, but clotting function deteriorates
Solution Approach 1:
The patent extracts the essential hemostatic components (microparticles and growth factors) from stored platelets and stabilizes them in a formulation that maintains clotting function over extended periods. This allows the composition to benefit from the availability of stored platelets while preserving the critical clotting parameters through careful formulation and stabilization techniques.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The freeze-dried platelet compositions effectively accelerate clot formation, enhance thrombin-generating capacity, and contribute to tissue regeneration by providing essential growth factors, making them suitable for rapid hemostasis and wound healing in various settings.
Implementation Method 1
The freeze-dried platelet compositions effectively accelerate clot formation, enhance thrombin-generating capacity, and contribute to tissue regeneration
Implementation Method 2
Development of freeze-dried platelet compositions that include platelets and microparticles, which can be rehydrated for use as injectable or topical treatments
Data Source
AI summary
The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a hemostat, such as for treating bleeding or injuries associated with bleeding. It also provides methods of treating injuries or wounds, and methods of causing blood to clot. Likewise, it provides methods of promoting healing of wounds or of healing wounds.