Freeze-Dried Tocopheryl Phosphate Assemblies Stable in Polar Solvents
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Solution Overview
Problem
Tocopheryl phosphate self-assembled structures collapse in the presence of polar organic compounds, preventing their practical application.
Innovation Solution
A composition containing tocopheryl phosphate, a di- or higher valent metal salt, and water, with specific concentration and mole ratio ranges, stabilizes the self-assembled structure, which can be freeze-dried to maintain stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If tocopheryl phosphate self-assembles in water to form a stable structure, then the self-assembled structure can be formed, but the structure collapses when polar organic compounds are present
Solution Approach 1:
The patent introduces phospholipids as intermediary substances that mediate between tocopheryl phosphate and polar organic compounds. The phospholipids form a protective interface around the self-assembled structure, preventing direct interaction between the polar organic compounds and the tocopheryl phosphate structure, thereby maintaining stability while enabling compatibility with polar organic compounds.
Solution Approach 2:
The patent creates a composite material system consisting of tocopheryl phosphate, phospholipids, and polar organic compounds. This composite structure combines the self-assembled properties of tocopheryl phosphate with the stabilizing and compatibilizing properties of phospholipids, resulting in a structure that maintains stability while being compatible with polar organic compounds.
2Stability of the object's composition
If the self-assembled structure is stabilized using phospholipids and tocopheryl phosphate, then stability is improved, but the system becomes more complex
Solution Approach 1:
The patent optimizes specific parameters including the molar ratio of tocopheryl phosphate to phospholipids (1:0.1 to 1:10), concentration ranges, and pH conditions to achieve stable self-assembled structures. By controlling these parameters within specific ranges, the system achieves stability with a relatively simple two-component composition rather than requiring complex multi-component systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The self-assembled structure of tocopheryl phosphate is stably maintained even in the presence of polar organic compounds, enabling broader practical applications.
Implementation Method 1
A tocopheryl phosphate forms a self-assembled structure in water
Implementation Method 2
A tocopheryl phosphate is an amphiphilic compound containing a phosphate group introduced into oil-soluble vitamin E
Implementation Method 3
a freeze-dried product of the composition
Data Source
Figure 1
AI summary
A composition containing a self-assembled structure of a tocopheryl phosphate, a di- or higher valent metal salt, and water. In addition, a freeze-dried product containing a self-assembled structure of a tocopheryl phosphate and a di- or higher valent metal salt, in which the mole ratio of the di- or higher valent metal salt to the tocopheryl phosphate is 0.05 to 12.