Complete Freund's Adjuvant Eyelid Disease Model
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Solution Overview
Problem
There is a lack of a suitable model animal and method for evaluating the therapeutic or prophylactic effects of drugs against eyelid diseases such as blepharitis and meibomian gland dysfunction, as no previous method has considered the influence of administering complete Freund's adjuvant on mammalian eyelids.
Innovation Solution
Administering complete Freund's adjuvant to mammals, such as rats or rabbits, to induce conditions like plugging of meibomian gland orifices and telangiectasia, which can be used to evaluate the therapeutic or prophylactic effects of test substances, thereby creating a model animal and screening method for eyelid diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If complete Freund's adjuvant is administered to create an eyelid disease model, then the model reliability for evaluating therapeutic effects is improved, but the complexity of the administration method increases
Solution Approach 1:
The patent applies preliminary action by pre-administering complete Freund's adjuvant to mammals before testing therapeutic substances. This creates the eyelid disease model (plugging of meibomian gland orifices and/or telangiectasia) in advance, establishing a reliable baseline condition for subsequent evaluation of therapeutic or prophylactic effects of test substances.
2Measurement precision
If complete Freund's adjuvant is administered to induce plugging and telangiectasia, then the measurement precision of therapeutic effects is improved, but the time required for model creation increases
Solution Approach 1:
The patent performs the model-creating action in advance by administering complete Freund's adjuvant before conducting therapeutic effect evaluations. This preliminary creation of the eyelid disease model (with plugging of meibomian gland orifices and/or telangiectasia) allows for precise measurement of therapeutic effects without time pressure during the actual evaluation phase.
3Productivity
If complete Freund's adjuvant is administered to create a disease model, then the productivity of drug screening is improved, but the quantity of substances required for evaluation increases
Solution Approach 1:
The patent applies preliminary action by creating the eyelid disease model (through complete Freund's adjuvant administration-induced plugging and telangiectasia) before conducting the screening. This allows multiple test substances to be evaluated on already-established models, improving screening productivity without requiring excessive amounts of test substances, as the model creation is a one-time preliminary step.
Data Source
AI summary
A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.