Frozen Composition Spray for Deeper Skin Penetration
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Solution Overview
Problem
Existing methods for delivering compositions to the skin, such as application and injection, face challenges in achieving consistent penetration depth and minimizing skin damage, with limited absorption due to the lipid layer and potential harm to the skin.
Innovation Solution
A method and device for freezing and spraying a composition using a mixing spray system that includes a refrigerant and composition guide, controlling the freeze ratio to ensure a portion of the composition reaches the skin in a solid state, enhancing penetration by adjusting the refrigerant pressure and temperature to achieve a freeze ratio of at least 5%.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the composition is applied to the skin, then the skin is not damaged, but the penetration ability is insufficient due to the lipid layer barrier
Solution Approach 1:
The composition is frozen into solid particles, changing its physical state from liquid to solid. This phase change enables the composition to physically penetrate through the lipid layer barrier of the skin, overcoming the limitation of topical application where the lipid layer blocks absorption.
Solution Approach 2:
The composition is divided into fine frozen particles through freezing and spraying. This segmentation into small particles increases the surface area and enables better penetration through the skin barrier compared to bulk liquid application.
2Reliability
If the composition is injected into the skin, then deep penetration is achieved, but skin damage occurs causing pain and swelling
Solution Approach 1:
The mechanical injection system (needles, syringes) is replaced with a freeze spray system that delivers frozen particles through aerosolization. This substitution achieves deep penetration without physical needle insertion, eliminating pain and tissue damage while maintaining effective delivery.
Solution Approach 2:
The composition undergoes phase transition from liquid to solid frozen particles during spraying. This phase change allows the composition to penetrate the skin effectively without requiring mechanical injection, thus avoiding skin damage while achieving deep delivery.
3Ease of operation
If the composition is sprayed onto the skin, then non-invasive delivery is achieved, but penetration depth is insufficient
Solution Approach 1:
The composition is frozen into solid particles before spraying, changing its physical properties. This phase change enables the sprayed particles to penetrate deeper into the skin compared to liquid spray, achieving effective delivery without invasive procedures.
Solution Approach 2:
The composition is atomized into fine frozen particles through spraying. This segmentation into small particles enhances penetration capability while maintaining the non-invasive nature of spray delivery, overcoming the limitation of shallow penetration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the composition to penetrate below the epidermis and stratum corneum, increasing the amount absorbed into the skin while minimizing damage, with improved penetration efficiency and consistency.
Implementation Method 1
spraying, by using the mixing spray system, the composition with the refrigerant to the target region... a part of the composition in the liquid state being frozen and reaching the target region as the composition in a solid state
Implementation Method 2
a part of the composition in the liquid state being frozen and reaching the target region as the composition in a solid state... a freeze ratio representing a ratio of the composition in the solid state compared to the composition in the liquid state
Data Source
Figure 1
Figure 2
Figure 3(a)~3(c)
AI summary
The present disclosure relates generally to a method of providing a frozen composition and a device therefor and, more specifically, to a method of spraying a composition in a frozen state to a target region and a device therefor. A composition in a liquid state is sprayed together with a refrigerant, and the composition is frozen into a solid state by the refrigerant having a relatively low temperature and reaches the target region. The composition in a solid state has the effect of improving skin penetration compared to the composition in a liquid state.