Frozen Malignant Tissue Pulverization for Immune Response
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Solution Overview
Problem
Current T cell immunotherapy for cancer treatment is hindered by high costs, lengthy research and development processes, and scientific challenges such as temperature, pressure, and sterilization issues that affect the viability of T cells, leading to inefficient and costly failures.
Innovation Solution
A method involving biopsying a malignant tissue sample, freezing it with liquid nitrogen, mechanically pulverizing it, and injecting the pulverized sample into the patient to induce an immune response, which includes using a solvent to protect the sample and a crusher tool for pulverization to expose epitopes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional T cell immunotherapy methods are used, then immune response can be induced, but the treatment becomes costly and time-consuming due to complex incubation and harvest processes
Solution Approach 1:
The patent changes the physical state parameter of the tissue sample by freezing it, which fundamentally alters the subsequent processing requirements. Frozen tissue can be stored and processed without maintaining live cell cultures, eliminating the need for complex incubation environments and reducing processing time while maintaining immune response induction capability
Solution Approach 2:
The patent extracts the malignant tissue from the patient and processes it outside the body through freezing and mechanical pulverization. This extraction allows the epitopes to be prepared in advance without requiring live T cell cultures, significantly reducing the time and cost associated with traditional immunotherapy R&D
2Reliability
If traditional T cell immunotherapy methods are used, then immune response can be induced, but the treatment cost increases due to expensive incubation and harvest processes
Solution Approach 1:
The patent uses frozen tissue samples that can be processed relatively quickly and discarded after a single use. The frozen state allows for simple mechanical processing without expensive culture media, specialized equipment, or prolonged incubation periods, dramatically reducing treatment costs while maintaining the ability to induce immune response
Solution Approach 2:
By changing the tissue to a frozen state, the patent eliminates the need for expensive live cell culture conditions including controlled temperature incubators, humidity control, and sterile maintenance equipment. The frozen tissue can be processed with simple mechanical tools, reducing manufacturing costs significantly
3Reliability
If T cells are grown outside the body, then immune response can be induced, but temperature, pressure, and sterilization factors alter the final results
Solution Approach 1:
The patent extracts and processes malignant tissue outside the body through freezing and mechanical pulverization to expose epitopes. This approach eliminates the need for complex in vivo T cell manipulation while still providing the necessary immunogenic components for inducing an immune response
Solution Approach 2:
The patent changes the tissue to a frozen state and processes it mechanically rather than through biological cultivation. This parameter change eliminates sensitivity to temperature fluctuations, pressure changes, and sterilization requirements that plague live T cell cultures, simplifying the process while maintaining reliability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides a cost-effective and efficient method to induce an immune response, reducing the monetary and temporal burdens of traditional immunotherapy while ensuring viable T cell harvests by mechanically exposing epitopes in the frozen tissue sample.
Implementation Method 1
freezing the malignant tissue sample with liquid nitrogen
Data Source
AI summary
A method of inducing an immune response in a patient is provided. The method comprising biopsying a malignant tissue sample from a patient, freezing the malignant tissue sample to produce a frozen malignant tissue sample, mechanically pulverizing the frozen malignant tissue sample, and injecting the mechanically pulverized malignant tissue sample into said patient.