5-D-fructose dehydrogenase agent for reducing food calorie content
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for reducing calorie content in food are ineffective, leading to unsustainable weight loss and significant side effects, and do not address the high fructose consumption linked to obesity and metabolic syndrome without altering nutrition habits.
Innovation Solution
An agent containing 5-D-fructose dehydrogenase, optionally combined with glucose isomerase, that converts fructose to 5-keto-D-fructose and glucose to fructose, reducing their bioavailability and calorie content in food, allowing for the consumption of fructose-containing foods without weight gain or health risks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If fructose is used as a sweetener in food, then sweetness and energy content are improved, but calorie intake increases leading to obesity and metabolic syndrome
Solution Approach 1:
The patent applies parameter changes by chemically modifying fructose through dehydrogenation to convert it into 5-keto-D-fructose, a non-metabolizable compound. This chemical transformation changes the molecular structure of fructose while maintaining its sweetness, thereby eliminating its caloric content and harmful metabolic effects while preserving its functional properties as a sweetener
Solution Approach 2:
The patent uses an enzyme (dehydrogenase) as an intermediary to catalyze the conversion of fructose to 5-keto-D-fructose. This enzymatic mediator facilitates the selective chemical transformation of fructose in the digestive tract, converting the harmful substance into a benign form that cannot be metabolized for energy while still allowing the compound to reach the intestines and exert its sweetening effect
2Loss of energy
If current methods are used to reduce calorie content, then weight loss is achieved, but side effects occur and weight loss is unsustainable
Solution Approach 1:
The patent implements self-service by enabling the food itself to reduce its own caloric content through the addition of dehydrogenase enzyme. The enzyme resides in the food matrix and automatically converts fructose to 5-keto-D-fructose during digestion, eliminating the need for external intervention or behavioral changes to achieve sustained calorie reduction and weight management
Solution Approach 2:
The patent applies preliminary action by pre-converting fructose to 5-keto-D-fructose before the food is consumed. The dehydrogenase enzyme is incorporated into the food product in advance, so that the caloric reduction occurs automatically during the normal digestive process, ensuring sustainable weight loss without requiring post-consumption intervention
3Use of energy by moving object
If fructose is metabolized in the body, then energy is provided, but appetite suppression fails leading to overconsumption
Solution Approach 1:
The patent changes the metabolic parameter of fructose by converting it to 5-keto-D-fructose, which cannot enter metabolic pathways. This parameter change eliminates fructose's ability to provide energy while preserving its sweet taste, thereby disrupting the link between sweetness consumption and energy intake that normally fails to suppress appetite effectively
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The agent significantly reduces the usable calorie content of food, enabling sustainable weight management and safe consumption of fructose-containing foods, addressing obesity and related health issues without side effects.
Implementation Method 1
the conversion of fructose to 5-keto-D-fructose
Implementation Method 2
the conversion of glucose to fructose
Data Source
AI summary
There are disclosed compositions and methods for treating obesity using 5-D-fructose dehydrogenase. Other embodiments are also described.