Fructus Schisandrae Extract Mitigates Antineoplastic Toxicity

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Solution Overview

Problem

Antineoplastic agents used in chemotherapy often cause severe toxicities and side effects such as cardiovascular toxicity, hepatotoxicity, nephrotoxicity, suppression of bone marrow, immunosuppression, and alopecia, which current treatments fail to adequately mitigate.

Innovation Solution

The use of Fructus Schisandrae and its extracts, particularly dibenzocyclooctadiene lignans like schisandrin B, to prepare medicaments that reduce and prevent the toxicity and side effects of antineoplastic agents by administering them concurrently or following antineoplastic agent treatment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antineoplastic agents are used to treat tumors, then tumor treatment efficacy is improved, but toxic and side effects such as cardiovascular toxicity, hepatotoxicity, and nephrotoxicity occur

Engineering Contradiction:

Improvetumor treatment efficacyVSAvoidtoxic and side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Fructus Schisandrae and its active ingredients (dibenzocyclooctadiene lignans, schisandrin B) act as intermediary substances that protect normal tissues from antineoplastic agent damage. The extract is administered concurrently or sequentially with antineoplastic agents to reduce their toxic effects on cardiovascular system, liver, and kidneys without interfering with antitumor activity

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention converts the harmful polyphenolic compounds naturally present in Fructus Schisandrae into beneficial protective agents. The extract, which contains compounds that could potentially be toxic, is shown to have cardioprotective, hepatoprotective, and nephroprotective effects when used with antineoplastic agents, transforming potential harm into therapeutic benefit

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Object-affected harmful factors

If Fructus Schisandrae extract is administered to reduce toxicity, then side effects are minimized, but treatment complexity increases

Engineering Contradiction:

Improveside effectsVSAvoidtreatment complexity

Core Design Contradiction:

Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

Fructus Schisandrae extract serves multiple protective functions simultaneously - it provides cardioprotection, hepatoprotection, and nephroprotection against various types of antineoplastic agents (anthracyclines, bleomycin, cisplatin, etc.). This single extract addresses multiple organ toxicities that would otherwise require separate protective measures

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The invention optimizes the extract parameters including solvent type (ethanol preferred), concentration (10-50 mg/kg body weight), and administration timing (concurrent or post-treatment) to achieve maximum protective effect while maintaining simplicity. The extract is prepared using straightforward extraction methods with common solvents

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS8404287B2Use of <i>Fructus schisandrae </i>and extracts thereof in preventing and decreasing toxic and side effects of antineoplastic drugs

Publication Date: 2013.03.26 ZHEJIANG DINGHUI PHARM

AI summary

Use of Fructus schisandrae in preparation of medicaments for preventing and reducing toxicity and side effects of antineoplastic agents. The toxicity and side effects of antineoplastic agents are cardiovascular toxicity, hepatotoxicity, nephrotoxicity, suppression of bone marrow, immunosuppression, or alopecia etc induced by antineoplastic agents. Fructus schisandrae and extracts thereof, especially ethanol extracts, schisandrin B, are effective in reducing antineoplastic agent's toxicity and side effects.