Compositions and method for treating and preventing complications of obesity

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Solution Overview

Problem

The increasing prevalence of obesity and related metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and atherosclerosis, is driven by dysregulated immune responses and gut microbiota dysbiosis, leading to inflammation and lipid accumulation in tissues.

Innovation Solution

A composition comprising a dry powder of fruits and vegetables, supplemented at 15% of the diet, which improves gut microbiota diversity, reduces pro-inflammatory cytokines like TNFα and ceramides, and suppresses adipose tissue inflammation, thereby preventing hepatic steatosis and atherosclerosis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Use of energy by moving object

If a high fat diet is consumed, then energy intake increases, but hepatic steatosis and adipose tissue inflammation occur

Engineering Contradiction:

Improveenergy intakeVSAvoidhepatic steatosis and inflammation

Core Design Contradiction:

Use of energy by moving objectVSObject-affected harmful factors

Solution Approach 1:

The F&V mixture acts as an intermediary substance that modifies the interaction between high fat diet components and host metabolism. The phytochemicals and fiber in F&V mediate the metabolic effects, reducing inflammation and preventing hepatic steatosis even when high fat intake is maintained, without requiring weight loss or dietary fat reduction

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes key metabolic parameters including gut microbiota composition, inflammatory cytokine levels (TNFα), and ceramide levels. These parameter changes occur independently of weight loss, allowing energy intake to remain high while harmful metabolic outcomes are prevented through biochemical modulation

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If weight loss is achieved to prevent metabolic disorders, then hepatic steatosis reduces, but the composition should still be effective without weight loss

Engineering Contradiction:

Improveweight lossVSAvoideffectiveness without weight loss

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The F&V mixture provides self-service benefits by directly modulating metabolic pathways and gut microbiota to prevent hepatic steatosis and inflammation. The composition works through its own active components (phytochemicals, fiber) to produce therapeutic effects independent of weight change, making weight loss unnecessary for efficacy

Inventive Principle:

Principle #25Self-service

3Adaptability or versatility

If gut microbiota diversity is increased, then inflammation is reduced, but the mechanism should be clear and actionable

Engineering Contradiction:

Improvegut microbiota diversityVSAvoidmechanism clarity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The F&V mixture performs preliminary action by pre-modulating gut microbiota composition before pathological changes occur. The diverse phytochemicals in F&V selectively promote beneficial bacterial growth and inhibit pathogenic bacteria, establishing a protective microbiota profile that prevents inflammation and hepatic steatosis development

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS12369611B2Compositions and method for treating and preventing complications of obesity

Publication Date: 2025.07.29 TUFTS UNIV

AI summary

Provided herein are compositions and methods for treating, preventing, and reducing the risk of obesity and related diseases and conditions. In particular, provided herein is a composition comprising a dry powder of fruits and vegetables and uses thereof.