Functionalized Pre-polymer for Wet Tissue Adhesion
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Solution Overview
Problem
Current tissue adhesives for cardiac and vascular applications are ineffective in dynamic wet conditions, toxic, or exhibit weak adhesive properties, making them unsuitable for internal use in cardiac chambers and blood vessels, and they often require mechanical fixation, which can cause tissue injury and complications.
Innovation Solution
A biocompatible, activated, and functionalized pre-polymer with negatively-charged groups is developed, which remains stable and effective in bodily fluids, providing strong adhesive forces upon curing, allowing for tissue sealing and device attachment without mechanical entrapment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If current tissue adhesives (cyanoacrylate, fibrin sealant) are used for cardiac and vascular applications, then adhesive properties are achieved, but they are washed out or cured under dynamic wet conditions and exhibit toxicity
Solution Approach 1:
The patent changes the chemical parameters of the adhesive by using polyesters with specific functional groups (carboxyl, hydroxyl, amine) and controlling molecular weight and composition to achieve both adhesive strength and stability in wet physiological conditions while being biocompatible
Solution Approach 2:
The patent creates a composite adhesive system combining polyester pre-polymer with specific functional groups that provide both adhesion through chemical interaction with tissue proteins and stability in wet conditions through the polymer's inherent properties
2Reliability
If mechanical fixation methods are used for catheter-based closure devices, then device fixation is achieved, but tissue injury to critical structures occurs
Solution Approach 1:
The patent replaces mechanical fixation systems (sutures, clips, grippers) with a chemical adhesion system based on functional polymer that bonds to tissue through chemical interactions, eliminating mechanical compression and erosion of tissue
3Strength
If chemical reaction-based adhesives are used for tissue adhesion, then adhesive properties are achieved, but they become ineffective in the presence of blood
Solution Approach 1:
The patent modifies the chemical parameters of the adhesive by selecting functional groups (carboxyl, hydroxyl, amine) that maintain reactivity and adhesion capability in the presence of blood and physiological fluids, unlike other chemical adhesives that are deactivated by these conditions
4Strength
If reactive chemistry adhesives are used for tissue bonding, then adhesion strength is achieved, but tissue denaturation and inflammation occur
Solution Approach 1:
The patent carefully selects and controls the chemical parameters of the reactive groups in the polymer to achieve adhesion while minimizing tissue damage, using biocompatible functional groups that bond to tissue proteins without causing denaturation or severe inflammatory responses
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The pre-polymer achieves improved tissue sealing and adhesive strength, resisting movement of underlying tissues and maintaining effectiveness in the presence of blood and other bodily fluids, with a cured composition that is biodegradable and minimally inflammatory.
Implementation Method 1
achieve tissue adhesion only through chemical reaction with functional groups at the tissue surface
Implementation Method 2
U.S. Pat. No. 8,143,042 B2 describes biodegradable elastomers prepared by crosslinking a prepolymer containing crosslinkable functional groups, such as acrylate groups
Data Source
AI summary
The present disclosure relates to a composition comprising: a pre-polymer having activated groups and negatively-charged functional groups on a polymeric backbone. The present disclosure also relates to a method for preparing such a composition.