Functionalized Tissue Matrices with Chelated Metals
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Solution Overview
Problem
Current tissue treatment products face challenges with microbial contamination and bioactive substance diffusion, which can reduce their effectiveness in repairing or regenerating tissues, and they often lack antimicrobial properties to prevent infection.
Innovation Solution
Development of tissue treatment products comprising a porous material with covalently bound chelating agents and metals or metal-binding proteins, such as zinc or copper, which provide antimicrobial properties and serve as a platform for metalloenzymes or proteins like lysostaphin, reducing bioburden and enhancing tissue repair and regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If foreign tissue materials are implanted to provide a collagen-rich scaffold for tissue repair, then tissue repair and regeneration are promoted, but the risk of microbial contamination increases
Solution Approach 1:
The patent applies preliminary anti-action by pre-functionalizing the tissue scaffold with antimicrobial agents (metals bound to chelating agents) before implantation. This proactive approach establishes antimicrobial protection in advance, preventing microbial contamination rather than addressing it after it occurs, thereby resolving the contradiction between promoting tissue repair and preventing infection.
Solution Approach 2:
The patent uses composite materials by combining the tissue scaffold (collagen-rich extracellular matrix) with antimicrobial functional components (metals such as silver, zinc, or copper bound to chelating agents like EDTA or DTPA). This creates a multifunctional composite material that simultaneously provides structural support for tissue repair and antimicrobial protection, resolving the contradiction between repair effectiveness and infection risk.
2Reliability
If bioactive substances are coated on implanted materials to promote tissue repair, then tissue regeneration is enhanced, but the substances diffuse out and lose their beneficial effects
Solution Approach 1:
The patent extracts the problematic diffusion issue by separating the bioactive substance (metal ion) from the scaffold material through covalent binding via chelating agents. The metals are chemically anchored to the scaffold, preventing them from diffusing away while remaining bioavailable for their therapeutic effects, thus resolving the contradiction between enhancing regeneration and retaining substances.
Solution Approach 2:
The patent changes the physical-chemical parameters of the bioactive substances by binding metals to chelating agents covalently attached to the scaffold. This chemical modification alters the mobility and retention characteristics of the metals, allowing them to remain localized on the scaffold for extended periods while maintaining their biological activity, thereby resolving the contradiction between enhancement and retention.
3Object-affected harmful factors
If metals are bound to chelating agents on the tissue scaffold, then antimicrobial properties are provided, but the device complexity increases
Solution Approach 1:
The patent applies universality by using a general platform approach: a tissue scaffold functionalized with chelating agents that can bind various metals (silver, zinc, copper, etc.). This single platform design provides antimicrobial protection through multiple possible metal choices without requiring separate complex systems for each metal, resolving the contradiction between providing antimicrobial protection and maintaining simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The products offer a scaffold for native cell migration and proliferation, reduce microbial contamination, and maintain a higher local concentration of antimicrobial agents, leading to faster healing and reduced bioburden at the implant site, while minimizing immune response and substance diffusion.
Implementation Method 1
wherein at least one chelating agent is covalently bound to the porous material
Implementation Method 2
tissue treatment products comprising acellular tissue matrices and/or other synthetic materials that are bound to one or more chelating agents, metals, and/or metal-binding proteins
Data Source
AI summary
Disclosed herein are tissue treatment products that have been bound to at least one chelating agent. Also disclosed are tissue treatment products that have been functionalized with at least one metal and/or at least one metal-binding protein. The tissue treatment products can have antimicrobial properties and/or factors that promote or enhance native cell migration, proliferation, and/or revascularization after implantation into a subject. Also disclosed are methods of making and using the tissue treatment products. The tissue treatment products can be implanted into a tissue in need of repair, regeneration, healing, treatment, and/or alteration and can promote or enhance native cell migration, proliferation, and/or revascularization.