Fungicidal Combinations for Crop Disease Control
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Solution Overview
Problem
Current fungicides face challenges in effectively controlling fungal diseases due to varying fungal resistance and crop sensitivity, requiring alternative treatments with broader disease control and lower dosage requirements.
Innovation Solution
A fungicidal combination comprising demethylation inhibitors, succinate dehydrogenase inhibitors, RNA polymerase I inhibitors, and ß-tubulin assembly inhibitors, or multi-site fungicides, which are applied to enhance fungal control, overcome resistance, and reduce phytotoxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional single fungicides are used, then application simplicity is maintained, but fungal resistance develops and disease control effectiveness decreases
Solution Approach 1:
The patent combines multiple fungicides with different modes of action (demethylation inhibitor, succinate dehydrogenase inhibitor, RNA polymerase I inhibitor, and ß-tubulin assembly inhibitor) into a single composition. This merging approach achieves synergistic effects that enhance disease control effectiveness while preventing fungal resistance development, as each fungicide targets different fungal growth mechanisms
Solution Approach 2:
The invention creates a composite fungicidal composition containing four distinct fungicide classes with different modes of action. This composite structure allows the formulation to address multiple fungal resistance mechanisms simultaneously while maintaining broad-spectrum disease control, effectively solving the contradiction between reliability and adaptability
2Reliability
If higher fungicide dosages are applied to overcome resistance, then disease control improves, but crop phytotoxicity increases
Solution Approach 1:
By combining multiple fungicides at lower individual dosages into a synergistic formulation, the patent achieves effective disease control without the need to increase overall application rates. The synergistic interaction between the four fungicide classes allows each component to work at sub-optimal levels while collectively delivering superior control, thereby reducing phytotoxicity risks
Solution Approach 2:
The invention changes the dosing parameters by distributing the total fungicidal effect across four different active ingredients at lower individual concentrations. This parameter adjustment maintains disease control effectiveness while reducing the phytotoxic impact on crops, as no single fungicide is applied at potentially harmful high doses
3Reliability
If multiple fungicides are combined, then disease control effectiveness and resistance management improve, but formulation complexity increases
Solution Approach 1:
The patent merges four different fungicide classes into a single integrated formulation, simplifying the application process for farmers while maintaining the complexity benefits of multi-mode-of-action chemistry. This single-product approach eliminates the need for separate applications of each fungicide, reducing formulation and application complexity despite containing multiple active ingredients
Data Source
AI summary
The present disclosure relates to fungicidal combinations, compositions including the fungicidal combinations, and to a method of controlling fungal diseases using the combinations. The combination includes at least one demethylation inhibitor; at least one succinate dehydrogenase (SDH) inhibitor; at least one RNA polymerase I inhibitor; and at least one ß-tubulin assembly inhibitor and/or at least one multi-site fungicide.