Fungicidal Combinations Synergy Multisite Systemic Fungicides
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Solution Overview
Problem
There is a need for fungicidal combinations that offer broader disease control, are curative and preventive, and require lower dosages to overcome resistance and phytotoxicity issues in crop protection, as crop tolerance decreases and fungal resistance increases with current multisite and systemic fungicides.
Innovation Solution
A combination of at least one multisite fungicide with at least three systemic fungicides, specifically DMI, QoI, and SDHI fungicides, which work synergistically to inhibit fungal growth through multiple sites of action, reducing fungal disease incidence and increasing crop yields while minimizing phytotoxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If higher dosages of current fungicides are used to control fungal diseases, then disease control effectiveness is improved, but crop phytotoxicity increases
Solution Approach 1:
The patent combines multiple fungicides with different modes of action (SDHI, DMI, QoI, and multisite fungicides) into a single composition. This synergistic combination achieves enhanced disease control effectiveness while allowing lower dosages of each individual fungicide, thereby reducing crop phytotoxicity compared to using higher dosages of single fungicides.
Solution Approach 2:
The invention creates a composite fungicidal composition containing four different fungicide classes with distinct modes of action. This composite approach provides broader spectrum control and improved reliability while maintaining lower individual dosages, thus reducing harmful effects on crops.
2Reliability
If higher dosages of fungicides are used to overcome fungal resistance, then disease control is improved, but dosage requirements and cost increase
Solution Approach 1:
The patent combines four different fungicide classes (SDHI, DMI, QoI, and multisite) with different modes of action into a single composition. This synergistic combination overcomes fungal resistance more effectively than single fungicides, achieving improved disease control while maintaining lower total dosage requirements compared to using higher dosages of individual fungicides.
Solution Approach 2:
The invention changes the parameter of fungicide composition by incorporating multiple fungicide classes with different modes of action. This parameter change allows the composition to overcome resistance mechanisms that single fungicides cannot, achieving effective disease control at optimized dosage levels.
3Quantity of substance
If single mode of action fungicides are used, then dosage requirements are lower, but fungal resistance develops more rapidly
Solution Approach 1:
The patent merges four different fungicide classes (SDHI, DMI, QoI, and multisite) with distinct modes of action into a single composition. This combination prevents fungal resistance from developing rapidly because the fungi would need to develop resistance to multiple different modes of action simultaneously, thereby improving resistance management while maintaining effective disease control.
Solution Approach 2:
The invention creates a composite fungicidal formulation containing multiple fungicide classes with different modes of action. This composite structure inherently manages resistance better than single-mode fungicides, as it presents multiple biochemical targets that fungi cannot easily resist, thus improving reliability for long-term disease management.
4Reliability
If broader spectrum fungicidal activity is achieved through multiple fungicide classes, then disease control effectiveness is improved, but formulation complexity increases
Solution Approach 1:
The patent combines four different fungicide classes into a single integrated composition that provides broad-spectrum disease control. While combining multiple active ingredients increases formulation complexity, the patent addresses this by providing specific guidance on compatibility and dosing, making the complex formulation practical for field use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of multisite and systemic fungicides provides effective and synergistic control of fungal diseases with reduced phytotoxicity and lower dosage requirements, enhancing crop yield and disease management compared to traditional combinations.
Implementation Method 1
These molecules specifically bind to the ubiquinone-binding site (Q-site) of the mitochondrial complex II, thereby inhibiting fungal respiration.
Implementation Method 2
inhibit fungal growth by inhibiting the ergosterol biosynthesis and thus plasma membranes
Implementation Method 3
act at the Quinone 'outer' (Qo) binding site of the cytochrome bc1 complex
Data Source
AI summary
Described herein are fungicidal combinations and compositions including at least one multisite fungicide and at least three systemic fungicides. Methods of controlling a fungal disease in a crop or a locus include applying an effective amount of the disclosed fungicidal combinations to the crop or to the locus.