Fungicidal Composition Synergy for Phytophthora Control

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Solution Overview

Problem

Current fungicides are inadequate for effectively controlling diseases caused by phytopathogens such as Phytophthora infestans and Plasmopara viticola, leading to significant yield losses in fruit and vegetable production, as they often lack sufficient crop tolerance and activity against these pathogens.

Innovation Solution

A novel fungicidal composition combining 1'-[2-(3,5-bis-difluoromethyl-pyrazol-1-yl)-acetyl]-1',2',3',4',6'-hexahydro-[4,4']bipyridinyl-2-carboxylic acid with compounds like ametoctradin, azoxystrobin, and others, which significantly enhances fungicidal activity and broadens the spectrum of phytopathogen control.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If customary fungicides are used alone, then application simplicity is maintained, but fungicidal activity against Phytophthora infestans and Plasmopara viticola is insufficient

Engineering Contradiction:
Improvefungicidal activityVSAvoidcomposition complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines component (A) with at least one compound from group (B) to create a synergistic fungicidal composition. This merging of different chemical classes (pyrazole derivatives with various other fungicides) achieves enhanced and broadened fungicidal activity against Phytophthora infestans and Plasmopara viticola that cannot be obtained with single substances alone.

Inventive Principle:
Principle #5Merging (Combining)

2Adaptability or versatility

If single fungicide compounds are used, then composition simplicity is maintained, but spectrum of phytopathogen control is limited

Engineering Contradiction:
Improvespectrum of controlVSAvoidcomposition structure
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The fungicidal composition according to the patent achieves multi-functionality by combining component (A) with various compounds from group (B), enabling the formulation to control a broad spectrum of phytopathogens including but not limited to Phytophthora infestans and Plasmopara viticola. This universal approach allows a single composition to address multiple disease threats.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Reliability

If higher application rates are used to improve efficacy, then fungicidal activity is enhanced, but crop tolerance is reduced

Engineering Contradiction:
Improvefungicidal efficacyVSAvoidcrop tolerance
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters by combining component (A) with compounds from group (B) in specific ratios (weight ratios from 1:10 to 10:1). This parameter optimization achieves enhanced fungicidal efficacy at lower application rates while maintaining crop tolerance, as the synergistic interaction allows reduced dosages compared to using single compounds.

Inventive Principle:
Principle #35Parameter changes

4Productivity

If existing fungicides are used, then current agricultural practices are maintained, but yield losses from late blight and downy mildew continue

Engineering Contradiction:
Improvecrop yieldVSAvoiddisease control effectiveness
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent provides a practical, readily applicable fungicidal composition that can be used in current agricultural practices. The composition uses known compounds from group (B) combined with component (A) to deliver immediate and effective protection against Phytophthora infestans and Plasmopara viticola, thereby preventing yield losses in potato and tomato production.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Data Source

PatentEP3174397B1Fungicidal compositions
Publication Date: 2019.12.25 SYNGENTA PARTICIPATIONS AG
  • EP3174397B1 patent drawing

AI summary

A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of formula (I) wherein R1 is difluoromethyl or trifluoromethyl and R2 is methyl, difluoromethyl, trifluoromethyl or cyclopropyl; and (B) at least one compound selected from compounds known for their fungicidal activity; and a method of controlling diseases on useful plants, especially leaf spot diseases on cereals.