Fungicidal Mixtures for F129L Qo Inhibitor-Resistant Soybean Rust
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Solution Overview
Problem
Phytopathogenic fungi with a F129L mutation in mitochondrial cytochrome b confer resistance to Qo inhibitors, making existing fungicides less effective against infestation in plants.
Innovation Solution
A fungicidal composition comprising a mixture of compounds (A) and (B) is applied to plants, where (A) includes methyl (Z)-2-(5-alkyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoates and (B) includes specific fungicides, effectively controlling or preventing infestation by targeting the resistant fungi.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Qo inhibitors are used to control phytopathogenic fungi, then fungal infestation is controlled, but resistance develops due to F129L mutation in mitochondrial cytochrome b
Solution Approach 1:
The patent combines a methoxyacrylate derivative (component A) with another fungicide (component B) to create a mixed composition that effectively controls Qo inhibitor-resistant fungi. The combination leverages different modes of action to overcome resistance while maintaining effectiveness.
Solution Approach 2:
The patent changes the chemical parameter by introducing a new class of compounds (methoxyacrylate derivatives with specific structural features at positions R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, R42, R43, R44, R45, R46, R47, R48, R49, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R71, R72, R73, R74, R75, R76, R77, R78, R79, R80, R81, R82, R83, R84, R85, R86, R87, R88, R89, R90, R91, R92, R93, R94, R95, R96, R97, R98, R99, R100) to replace or supplement Qo inhibitors, thereby changing the chemical mechanism of action to overcome resistance.
2Reliability
If new fungicidal compositions are developed to overcome resistance, then effectiveness against resistant fungi is improved, but composition complexity increases
Solution Approach 1:
The patent segments the fungicidal composition into two distinct components: a methoxyacrylate derivative (component A) and another fungicide (component B). This segmentation allows each component to target different aspects of fungal physiology, improving effectiveness against resistant strains while maintaining a manageable composition structure.
Data Source
AI summary
The present invention relates to a method of controlling or preventing infestation by phytopathogenic fungi in a plant, wherein said phytopathogenic fungi comprises a F129L mutation in the mitochondrial cytochrome b which confers resistance to Qo inhibitors.