Fungicide Formulation Stability via Lactamide Mediator
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Solution Overview
Problem
Conventional formulations of oxathiapiprolin and metalaxyl-M fungicides face challenges in stability over time and increased toxicity, particularly at varying temperatures and high active ingredient loads.
Innovation Solution
A composition comprising oxathiapiprolin, metalaxyl-M, and a lactamide compound, with the lactamide compound making up at least 40% of the formulation, which enhances temperature stability and reduces toxicity, including eye irritancy, by optimizing the ratio of active ingredients and incorporating emulsifiers and dispersing agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If conventional formulation approaches are used for oxathiapiprolin and metalaxyl-M mixture, then formulation can be made, but stability over time is insufficient
Solution Approach 1:
The patent introduces a specific solvent system comprising dimethyl amide ether and lactic acid dimethyl amide as intermediary substances that mediate between the two active ingredients oxathiapiprolin and metalaxyl-M. This solvent system acts as a bridge to ensure compatibility and stability of the mixture over time, resolving the formulation stability issue without requiring complex multi-component systems.
2Quantity of substance
If amount of active ingredients is increased, then fungicidal efficacy is improved, but toxicity becomes more complex to deal with
Solution Approach 1:
The patent optimizes the concentration parameters of the solvent system components (dimethyl amide ether and lactic acid dimethyl amide) to achieve a balance where high amounts of active ingredients can be formulated while maintaining acceptable toxicity levels. By carefully controlling the solvent composition ratios and concentrations, the formulation achieves both high active ingredient content and reduced eye irritancy.
3Stability of the object's composition
If high amount of metalaxyl-M is included, then temperature stability is optimized, but formulation complexity increases
Solution Approach 1:
The patent creates a composite solvent system combining dimethyl amide ether and lactic acid dimethyl amide in specific ratios. This composite solvent system provides enhanced temperature stability that allows high amounts of metalaxyl-M (at least 15% by weight) to be incorporated while maintaining formulation simplicity. The synergistic interaction between the two solvent components achieves temperature stability without requiring additional stabilizing agents or complex formulation structures.
Data Source
AI summary
This invention relates to a fungicidal composition comprising: a. oxathiapiprolin, b. metalaxyl-M, and c. a lactamide compound of formula I CH3CH(OH)C(═O)NR1R2 (I) wherein R1 and R2 are each independently hydrogen; or C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl, each of which is optionally substituted by up to three substituents independently selected from phenyl, hydroxy, C1-5 alkoxy, morpholinyl and NR3R4 where R3 and R4 are each independently C1-3 alkyl; or phenyl optionally substituted by up to three substituents independently selected from C1-3 alkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl, pyrrolidinyl, piperidinyl or azepanyl ring, each of which is optionally substituted by up to three substituents independently selected from C1-3 alkyl, the composition comprising at least 40% by weight of said lactamide compound, over the total weight of the composition.