Fusaricidin Bacterial Formulations for Plant Protection

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Solution Overview

Problem

Current formulations for fusaricidin-producing bacteria in crop protection often suffer from stability issues during storage and application, and their biological effectiveness is compromised by certain additives, necessitating the development of formulations that maintain efficacy and stability while preventing fungal infections in plants.

Innovation Solution

Formulations comprising spores of fusaricidin-producing bacteria, combined with specific nonionic and ionic surface-active additives, which enhance the biological efficacy and stability of the spores when applied to plants, including the use of category 1 additives like poloxamers and polyvinylpyrrolidones, and category 2 additives like sodium lauryl ether sulfates, while minimizing the detrimental effects of category 3 additives.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If conventional additives are used in formulations for fusaricidin-producing bacteria, then formulation stability is improved, but biological effectiveness deteriorates

Engineering Contradiction:
Improveformulation stabilityVSAvoidbiological effectiveness
Core Design Contradiction:
Stability of the object's compositionVSReliability

Solution Approach 1:

The patent segments additives into three distinct categories (Category 1: compatible additives like sugars and amino acids; Category 2: incompatible additives like certain surfactants; Category 3: optional additives with conditional compatibility). This segmentation allows formulators to selectively combine additives while maintaining both formulation stability and biological effectiveness by avoiding harmful interactions between incompatible substances.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent establishes specific concentration thresholds for different additive categories to optimize performance. Category 1 additives are included at concentrations that enhance stability without compromising efficacy, while Category 2 additives are excluded or limited to minimal concentrations. Category 3 additives are used at controlled levels based on specific formulation requirements, allowing parameter optimization for both stability and effectiveness.

Inventive Principle:
Principle #35Parameter changes

2Duration of action of stationary object

If formulation stability is enhanced through additives, then storage duration is improved, but biological effectiveness deteriorates

Engineering Contradiction:
Improvestorage durationVSAvoidbiological effectiveness
Core Design Contradiction:
Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent incorporates Category 1 additives (such as sugars, amino acids, and protective proteins) into the formulation during manufacturing to pre-establish stable conditions for spore protection during storage. These additives create a protective environment that maintains spore viability and biological effectiveness throughout the storage period, allowing long-term stability without compromising subsequent effectiveness when applied to plants.

Inventive Principle:
Principle #10Preliminary action

3Ease of operation

If certain additives are included to improve formulation properties, then ease of application is improved, but biological effectiveness deteriorates

Engineering Contradiction:
Improveease of applicationVSAvoidbiological effectiveness
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent uses Category 1 additives as intermediary substances that facilitate formulation properties (such as adhesion, spreading, and suspension) without interfering with the biological activity of fusaricidin-producing bacteria. These intermediary substances act as bridges between the biological active ingredients and the application environment, improving ease of application while preserving effectiveness by avoiding direct interaction that would compromise bacterial viability or toxin production.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulations provide enhanced protection against fungal infections, maintain stability during storage and application, and ensure effective coverage of plant surfaces, thereby improving crop protection outcomes.

Implementation Method 1

at least one category 1 additive is selected from at least one group of additives 1a) to 1f): 1a) poloxamers, polyethylene glycol (A)—polypropylene glycol (B) block copolymers... 1b) polyvinylpyrolidines, polyvinylacetates... 1c) polyoxyethylene sorbitol fatty acid esters ('polysorbates')... 1d) fatty acid glycerol esters... 1e) alcohol alcoxylates... 1f) alkyl glucosides

Methodology Applied
Scientific EffectSurface tension reduction: Surfactant

Implementation Method 2

at least one category 2 additive is selected from at least one group of additives 2a) to 2c) 2a) polyethylene glycol-grafted polyacrylates, and salts thereof... 2b) ethoxylated polyethylene imines... 2c) sodium lauryl ether sulfates

Methodology Applied
Scientific EffectEmulsification: Emulsion

Implementation Method 3

2a) polyethylene glycol-grafted polyacrylates, and salts thereof, preferably sodium salts thereof

Methodology Applied
Scientific EffectDispersion: Dispersion (of waves)

Data Source

PatentUS20230292765A1New agrochemical formulations for fusaricidin producing bacteria
Publication Date: 2023.09.21 BASF SE
  • US20230292765A1 patent drawing

AI summary

The present invention is directed to spraying liquid suitable for spraying plants, comprising spores of fusaricidin producing bacteria, at least one category (1) additive and/or at least one category (2) additive and less than 81 g per hectare of a category (3) additive, to solid and liquid formulations comprising spores of fusaricidin producing bacteria, at least one category (1) additive and/or at least one category (2) additive and optionally a category (3) additive, as well as to methods to control phytopathogenic fungi on plants applying such spraying liquids or formulations.