Fused Mescaline Derivatives With N-Propylamine for Fewer Side Effects
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Solution Overview
Problem
Mescaline, a psychoactive compound with therapeutic potential, is associated with adverse side effects such as panic attacks, paranoia, and nausea, necessitating the development of improved derivatives.
Innovation Solution
Development of fused heterocyclic mescaline derivatives with a substituted N-propylamine chain, including specific chemical structures and synthesis methods, to enhance therapeutic efficacy and reduce side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If mescaline is used as a psychoactive compound, then therapeutic potential and recreational use are achieved, but adverse side effects such as panic attacks, paranoia, and nausea occur
Solution Approach 1:
The patent applies local quality by introducing specific substitutions at particular positions on the phenethylamine structure. The N-propylamine chain with fused heterocyclic rings at specific positions (such as indan, tetrahydroisoquinoline, or chroman structures) modifies local molecular properties to enhance therapeutic effects while reducing adverse side effects like panic attacks, paranoia, and nausea associated with mescaline
Solution Approach 2:
The patent employs parameter changes by systematically varying structural parameters of the mescaline derivative, including the type of fused heterocyclic ring, substitution patterns on the N-propylamine chain, and positions of methoxy groups on the aromatic ring. These parameter modifications optimize the balance between therapeutic efficacy and reduction of harmful side effects
2Reliability
If fused heterocyclic mescaline derivatives with substituted N-propylamine chain are developed, then therapeutic efficacy is enhanced and side effects are reduced, but chemical synthesis complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the complex fused heterocyclic structure into modular components that can be synthesized separately and then assembled. The N-propylamine chain with fused heterocyclic rings (such as indan or tetrahydroisoquinoline moieties) can be prepared as discrete intermediates and then coupled to the 3,4,5-trimethoxyphenethylamine core, simplifying the overall synthesis process
Solution Approach 2:
The patent uses intermediary compounds as mediators in the synthesis pathway. Specific intermediates, such as substituted phenethylamines with protected functional groups or pre-formed heterocyclic building blocks, facilitate the construction of the final complex structure through stepwise reactions, reducing overall synthesis complexity
Data Source
AI summary
Disclosed are novel fused mescaline derivative compounds, notably substituted N-propylamine fused heterocyclic mescaline derivatives, including substituted N-propylamine fused dioxolane mescaline derivatives, and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.