Immunomodulatory Fusion Proteins for Multi-Pathway Immune Suppression
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Solution Overview
Problem
Current technologies lack effective methods to simultaneously target and modulate multiple immune pathways and receptor/ligand pairs to suppress or reduce pro-inflammatory immune responses.
Innovation Solution
Development of immunomodulatory fusion proteins that can bind and functionally target multiple proteins and signaling pathways, inhibiting receptor/ligand pairs and modulating immune responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple separate immunomodulatory proteins are used to target different immune pathways, then the ability to modulate multiple immune pathways is improved, but the device complexity and number of administrations required increase
Solution Approach 1:
The patent combines multiple immunomodulatory proteins into a single fusion protein molecule that can simultaneously target multiple immune pathways. This single fusion protein integrates the functionality of multiple separate proteins, reducing the number of administrations required while maintaining the ability to modulate multiple immune pathways simultaneously.
Solution Approach 2:
The fusion protein is designed with multi-functionality, enabling a single molecule to perform multiple immunomodulatory functions by targeting different receptor/ligand pairs. This universal approach allows one protein to replace multiple separate proteins, simplifying the treatment regimen while achieving comprehensive immune pathway modulation.
2Adaptability or versatility
If multiple separate immunomodulatory proteins are used to target different receptor/ligand pairs, then the coverage of immune pathways is improved, but the ease of operation and administration simplicity deteriorate
Solution Approach 1:
The patent merges multiple immunomodulatory proteins into a single fusion protein that can be administered as one agent. This combination approach maintains broad coverage of immune pathways while simplifying administration to a single dose, improving ease of operation compared to multiple separate protein administrations.
Solution Approach 2:
The fusion protein is engineered with universal multi-functional capabilities to target multiple receptor/ligand pairs simultaneously. This design enables one administration to achieve the therapeutic effect of multiple separate proteins, making the treatment easier to administer while maintaining comprehensive immune pathway coverage.
3Productivity
If a single fusion protein targets multiple receptor/ligand pairs, then the productivity and efficiency of immune modulation is improved, but the manufacturing precision and control of individual protein functions may worsen
Solution Approach 1:
The fusion protein is designed with distinct modular domains, each corresponding to a specific immunomodulatory protein component. These segmented functional domains are connected by flexible linkers that maintain the independence and specific functionality of each domain, allowing precise control of individual protein functions within the fusion construct while achieving high productivity through simultaneous multi-target engagement.
Data Source
AI summary
Provided herein are immunomodulatory fusion proteins and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the immunomodulatory fusion proteins and compositions. The immunomodulatory fusion proteins provided herein are useful in pharmaceutical compositions and methods of use (including, e.g., methods of suppressing or reducing (e.g., preventing) a pro-inflammatory immune response in a subject).