Gadolinium Complex for High-Field MRI Relaxivity
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Solution Overview
Problem
Current gadolinium-based MRI contrast agents have low water solubility and relaxivity, especially in high magnetic fields, limiting their effectiveness in providing clear tissue contrast.
Innovation Solution
A novel gadolinium complex with a specific chemical structure, coordinated with water molecules, is synthesized to enhance relaxivity and stability, allowing for improved contrast enhancement in high magnetic fields while targeting beta amyloid oligomers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional gadolinium-based contrast agents are used, then the MRI contrast can be obtained, but the relaxivity is low in high magnetic field conditions
Solution Approach 1:
The patent modifies the chemical structure parameters of the gadolinium complex by introducing specific linker groups (—(CH2)n—, —COO—, —CO—, —CONH—, —O—, or —C5N(RaRb)—*) and varying the number of water molecules coordinated to gadolinium (q=1-4), thereby optimizing the magnetic relaxation properties to achieve high relaxivity in high magnetic field conditions
Solution Approach 2:
The patent creates a composite gadolinium complex structure combining gadolinium ion with organic ligand systems containing nitrogen and oxygen donor atoms, forming a stable coordination complex that exhibits enhanced relaxivity while maintaining biostability and water solubility
2Reliability
If the gadolinium complex structure is optimized for high relaxivity, then contrast enhancement improves, but the complexity of the chemical structure increases
Solution Approach 1:
The patent systematically varies specific structural parameters including the linker type (—(CH2)n— with n=0-5, —COO—, —CO—, —CONH—, —O—, or —C5N(RaRb)—*), the number of coordinated water molecules (q=1-4), and substituent groups (R, Ra, Rb) to achieve optimal relaxivity while maintaining reasonable structural complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The gadolinium complex exhibits high relaxivity in high magnetic fields, maintaining effective contrast enhancement with lower doses and demonstrating high biostability, making it suitable for MRI applications, particularly in targeting beta amyloid oligomers.
Implementation Method 1
Magnetic Resonance Image (MRI) refers to a method of acquiring anatomical, physiological, and biochemical information images of a body using spin relaxation of hydrogen atoms in a magnetic field
Implementation Method 2
The contrast agent affects this relaxation to increase a difference in the relaxation between the types of tissues and thus to cause a MRI signal change
Implementation Method 3
gadolinium in the gadolinium complex may be coordinated with at least one water molecule
Implementation Method 4
a gadolinium complex as an MRI contrast agent with high relaxibity at a high magnetic field
Data Source
AI summary
Disclosed are a gadolinium complex with a high relaxibity at a high magnetic field, a method for synthesizing the complex, and an MRI contrast agent containing the gadolinium complex. The gadolinium complex may be expressed as a Chemical Formula 1: