GAG-Terminated Peptide for Memory Enhancement
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Solution Overview
Problem
Current treatments for memory and cognitive disorders, such as Alzheimer's and Parkinson's diseases, lack effective synthetic peptides with precise sequences and neuroprotective effects to improve brain function.
Innovation Solution
A peptide with a C-terminal region of GAG, derived from silk fibroin hydrolyzate or artificially synthesized, is developed, which can be stabilized with protection groups like acetyl or PEG, and used in pharmaceutical or food compositions to enhance memory, learning, and cognitive abilities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for memory and cognitive disorders, then existing therapeutic approaches are applied, but they lack effective synthetic peptides with precise sequences and neuroprotective effects
Solution Approach 1:
The patent applies parameter changes by optimizing the peptide sequence parameters (specific amino acid composition and length of 4-9 residues) to achieve both neuroprotective effects and precise sequence requirements. The controlled variable space includes peptide length, amino acid composition, and C-terminal GAG region configuration to resolve the contradiction between reliability and complexity.
Solution Approach 2:
The patent implements local quality by designing specific functional regions within the peptide, particularly the C-terminal GAG region, which provides neuroprotective activity while maintaining overall sequence precision. This localized functional design allows the peptide to achieve reliable neuroprotection without requiring complex overall structure.
2Reliability
If peptide length is increased to improve memory function, then neuroprotective effect is enhanced, but manufacturing complexity increases
Solution Approach 1:
The patent optimizes the peptide length parameter within a specific range of 4-9 amino acid residues to balance memory improvement efficacy with manufacturing ease. This parameter optimization ensures the peptide is long enough to provide neuroprotective effects but short enough for practical synthesis and production.
Solution Approach 2:
The patent uses composite design by combining specific amino acid sequences with a C-terminal GAG region, creating a structured peptide that achieves memory improvement effects while maintaining manageable complexity for manufacturing. The composite structure integrates functional domains that work together efficiently.
Data Source
AI summary
There is provided a composition for improving memory, learning ability, and cognitive ability and a method of enhancing a brain or cognitive function by administering the composition to a subject in need thereof. It has been confirmed that a peptide having a C-terminal region ended to GAG had an effect of improving the memory. In order for the peptide to have the effect, it has been confirmed that the peptide should be a peptide of which the length consists of at least 4 amino acids. Further, it has been confirmed that a peptide of which the length of the peptide having the C-terminal region ended to GAG consists of 5 to 9 amino acids has the same effect. As a result, the peptide of the present invention can be used as the composition for improving memory, learning ability, and cognitive ability, and the method of enhancing a brain or cognitive function.