Galega Water Composition with Cyclodextrin-Encapsulated Oil and Resveratrol

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Solution Overview

Problem

The hydrophobic nature of resveratrol and Hippophae rhamnoides oil prevents their dissolution in the aqueous Galega officinalis L. water, necessitating a solubilization method to create a composition with improved anti-ageing properties.

Innovation Solution

Encapsulating Hippophae rhamnoides oil and resveratrol with cyclodextrins, specifically β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin, to form inclusion complexes, enhancing their solubility and stability in water.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If Hippophae rhamnoides oil and resveratrol are directly mixed with Galega officinalis L. water, then the composition can be prepared, but the hydrophobic nature of the oil and resveratrol prevents their dissolution in the aqueous extract

Engineering Contradiction:

ImprovesolubilityVSAvoiddissolution capability

Core Design Contradiction:

Stability of the object's compositionVSEase of manufacture

Solution Approach 1:

Cyclodextrins are used as intermediary molecules that form inclusion complexes with the hydrophobic Hippophae rhamnoides oil and resveratrol, enabling their solubilization in the aqueous Galega officinalis L. water extract. The cyclodextrins act as mediators between the hydrophobic active ingredients and the hydrophilic aqueous medium, resolving the solubility contradiction.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If resveratrol is exposed to sunlight and high temperatures, then it can be used in the composition, but its antioxidant capacity and beneficial effects are reduced due to sensitivity to these environmental factors

Engineering Contradiction:

Improveantioxidant capacityVSAvoidsensitivity to sunlight and temperature

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Cyclodextrins form inclusion complexes with resveratrol in advance, creating a protective structure that cushions the resveratrol molecules from harmful environmental factors such as sunlight and high temperatures. This prior protection maintains the antioxidant capacity and beneficial effects of resveratrol when incorporated into the cosmetic composition.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

3Adaptability or versatility

If Galega officinalis L. water is used as the base, then it provides the desired cosmetic properties, but its aqueous nature does not allow dissolution of hydrophobic substances

Engineering Contradiction:

Improvecosmetic propertiesVSAvoiddissolution capability

Core Design Contradiction:

Adaptability or versatilityVSEase of operation

Solution Approach 1:

The composition creates a composite system combining the aqueous Galega officinalis L. water extract with cyclodextrin inclusion complexes of hydrophobic substances (Hippophae rhamnoides oil and resveratrol). This composite approach allows the aqueous base to maintain its cosmetic properties while the cyclodextrins enable the incorporation of hydrophobic active ingredients through molecular encapsulation.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The resulting composition exhibits increased antioxidant activity and effective anti-ageing properties, suitable for cosmetic and medical uses, with improved solubility and protection of resveratrol from environmental factors.

Implementation Method 1

solubilizing Hippophae rhamnoides oil in crude water extract of Galega officinalis L. through its molecular encapsulation with complexing agents

Methodology Applied

Scientific EffectMolecular encapsulation: Absorption (physical)

Implementation Method 2

cyclodextrins (CDs), which are cyclic oligosaccharides composed of 6, 7, 8 or more glucopyranose units linked by α-(1, 4) bonds, forming a conical structure with a hydrophobic internal cavity that can form inclusion complexes with a wide variety of molecules

Methodology Applied

Scientific EffectInclusion complexes: Absorption (physical)

Implementation Method 3

encapsulating it with CDs could be useful not only to improve its solubility in water, but also protect resveratrol molecules thereby maintaining their antioxidant capacity and beneficial effects

Methodology Applied

Scientific EffectEncapsulation protection: Absorption (physical)

Data Source

PatentEP4609848A1Method for obtaining a composition comprising crude water extract of galega officinalis l. water, hippophae rhamnoides oil and resveratrol

Publication Date: 2025.09.03 I-D ACTIVES SL

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AI summary

The present invention refers to the cosmetic and medical field. Particularly, the present invention refers to methods for obtaining a composition comprising crude water extract of Galega officinalis L. water, Hippophae rhamnoides oil and resveratrol. It also refers to anti-ageing compositions obtainable by any of these methods, and to the same compositions for use as a medicament. It also refers to the cosmetic use of these compositions for skin care or maintenance, preferably for decreasing a sign of cutaneous aging, and to a cosmetic method for skin care or maintenance, comprising applying or administering to a subject a preparation for skin care or maintenance, wherein the preparation comprises the cosmetic composition of the invention.