Gallbladder Mucosa Elimination for Cholecystitis Recurrence
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Solution Overview
Problem
Current treatments for acute cholecystitis, such as laparoscopic cholecystectomy, are invasive and do not prevent recurrence, while less invasive methods like cauterization of the gallbladder mucosa have temporary effects as the mucosa function is restored over time.
Innovation Solution
A method involving gallbladder drainage, mucosa treatment to reduce function, and subsequent contraction and maintenance of the gallbladder walls to prevent bile entry, using various access routes and tools like stents, cholangioscopes, and chemical treatments to eliminate the gallbladder's ability to form calculi.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If laparoscopic cholecystectomy is performed to treat acute cholecystitis, then the gallbladder is removed completely eliminating recurrence risk, but the treatment becomes invasive with surgical risks and longer recovery time
Solution Approach 1:
The patent extracts and eliminates only the functional mucosa membrane of the gallbladder through endoscopic cauterization, rather than removing the entire gallbladder organ. This selective extraction of the problematic functional component achieves disease prevention while preserving the organ structure, thereby reducing treatment invasiveness while maintaining recurrence prevention efficacy.
Solution Approach 2:
The patent introduces an endoscope as an intermediary tool to deliver cauterization energy to the gallbladder mucosa through the gastrointestinal tract lumen. This intermediary approach enables minimally invasive access to the target tissue without requiring external surgical incisions, thus resolving the contradiction between effective treatment and treatment invasiveness.
2Ease of operation
If cauterization of the gallbladder mucosa is performed to reduce its function, then the treatment is less invasive, but the effect is temporary as the mucosa function is restored over time
Solution Approach 1:
The patent performs preliminary elimination of gallbladder contents (bile and calculi) through endoscopic drainage before cauterization. This preliminary action prevents residual bile from causing inflammation after cauterization and accelerates the healing process, thereby extending the duration of treatment effect. Additionally, the patent may perform repeated cauterization sessions to ensure long-lasting functional elimination of the mucosa.
Solution Approach 2:
The patent employs periodic cauterization treatments at scheduled intervals to progressively and permanently eliminate mucosa function. By applying cauterization in multiple periodic sessions rather than a single treatment, the cumulative effect progressively destroys the regenerative capacity of the mucosa, thereby extending the duration of treatment effect from temporary to permanent.
3Reliability
If the gallbladder is drained and mucosa is treated to eliminate function, then bile concentration and calculi formation are suppressed, but the gallbladder structure remains and may still cause issues
Solution Approach 1:
The patent extracts and eliminates the functional mucosa membrane through endoscopic cauterization, thereby removing the tissue responsible for bile concentration and calculi formation. This selective extraction of the functional component while preserving the structural framework resolves the contradiction by eliminating calculi-generating capability while maintaining gallbladder structural integrity for potential future reconstruction or drainage functions.
Data Source
AI summary
A method of cholecystitis treatment according to an aspect of the present disclosure comprises a step A including contacting inner walls of a gallbladder to each other by constricting the gallbladder and a step B including maintaining the inner walls of the gallbladder contacting each other.