Gallic Acid Normalizes Bile Acid and Gut Microbiota Metabolism

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Solution Overview

Problem

Disturbances in bile acid, amino acid, and gut microbiota metabolism contribute to various metabolic disorders, including hypertension, hyperlipidemia, atherosclerosis, cholestasis, and gastrointestinal issues, for which current treatments are inadequate.

Innovation Solution

Administration of gallic acid or its pharmaceutically acceptable salts and esters to alleviate disturbances in bile acid, amino acid, and gut microbiota metabolism, effectively addressing the underlying metabolic imbalances.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments are used for metabolic disorders, then specific symptoms may be managed, but the underlying metabolic imbalances in bile acid, amino acid, and gut microbiota remain unaddressed

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidability to address multiple metabolic disturbances

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

Gallic acid is used as a single compound that simultaneously addresses multiple metabolic disturbances including bile acid metabolism, amino acid metabolism, and gut microbiota metabolism. This multi-functional approach allows one treatment to manage various metabolic disorders rather than requiring separate treatments for each condition.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The invention addresses different metabolic pathways (bile acid metabolism, amino acid metabolism, gut microbiota metabolism) as separate but interconnected segments. By targeting each segment with gallic acid, the treatment comprehensively manages the overall metabolic disorder while addressing specific metabolic imbalances individually.

Inventive Principle:

Principle #1Segmentation

2Ease of operation

If current therapeutic approaches are applied, then some disease symptoms may be relieved, but the causal metabolic disturbances remain unresolved

Engineering Contradiction:

Improvesimplicity of treatmentVSAvoidtherapeutic effectiveness

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The treatment addresses the root cause of metabolic disorders by normalizing metabolic disturbances before they progress to more severe disease states. By acting on the underlying metabolic imbalances in bile acid, amino acid, and gut microbiota metabolism, the treatment prevents disease progression rather than merely treating symptoms.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Gallic acid serves as an intermediary substance that mediates between the metabolic disturbances and the body's normal physiological functions. It acts as a bioactive compound that restores metabolic balance without requiring complex treatment protocols or multiple different substances.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS9744146B2Method for alleviating disturbance of bile acid metabolism, amino acid metabolism, and/or gut microbiota metabolism

Publication Date: 2017.08.29 CHINA MEDICAL UNIVERSITY(TW)

AI summary

A method for alleviating at least one of the disturbance of bile acid metabolism, the disturbance of amino acid metabolism, and the disturbance of gut microbiota metabolism in a subject, comprising administering to the subject a composition or a health food comprising an active component selected from the group consisting of gallic acid, a pharmaceutically acceptable salt of gallic acid, a pharmaceutically acceptable ester of gallic acid, and combinations thereof.