Galvanometer Scanning Mirror High-Speed Imaging Aberration Correction
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Solution Overview
Problem
Conventional high-speed imaging systems face limitations in achieving high-resolution images of targets within biological tissues due to sample-induced aberrations and the slow speed of spatial light modulators, which hinder real-time observation and deep tissue imaging.
Innovation Solution
A high-speed imaging system utilizing a two-axis galvanometer scanning mirror to adjust the angle of a plane wave, combined with an optical interferometer and an imaging controller that reconstructs and corrects aberration matrices to optimize image acquisition, enabling faster data collection and improved resolution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If spatial light modulators are used for wavefront shaping, then aberration correction is achieved, but the imaging speed becomes slow
Solution Approach 1:
The patent replaces the mechanical spatial light modulator with a galvanometer scanning mirror system. The galvanometer uses electromagnetic fields to control mirror rotation, providing much faster response times (microsecond range) compared to the millisecond-range spatial light modulators, thereby resolving the speed contradiction while maintaining aberration correction capability
Solution Approach 2:
The patent changes the operational parameters by using a galvanometer scanning system that rapidly varies the angle of incidence of light beams. This angular parameter modulation enables fast wavefront shaping without the speed limitations of spatial light modulators, achieving both accurate aberration correction and high imaging speed
2Measurement precision
If multiple iterations are performed for wavefront control, then measurement precision improves, but measurement time increases
Solution Approach 1:
The patent implements preliminary action by using a galvanometer scanning mirror to pre-scan and measure the wavefront aberrations before image acquisition. This preliminary wavefront characterization allows the system to calculate and apply correction patterns in advance, reducing the need for multiple iterative corrections during actual imaging and thereby minimizing time loss
Solution Approach 2:
The patent employs feedback mechanisms where the galvanometer scanning system rapidly measures wavefront distortions and feeds this information back to the control algorithm. This real-time feedback enables the system to converge on accurate aberration correction faster, reducing the number of iterations needed and minimizing measurement time while maintaining high precision
3Measurement precision
If fluorescence imaging is used for molecular specificity, then measurement precision improves, but device complexity and safety requirements increase
Solution Approach 1:
The patent extracts and eliminates the need for fluorescent labeling agents by using label-free optical coherence tomography imaging. The system achieves molecular specificity through intrinsic optical properties of tissues and advanced signal processing, removing the complexity and safety concerns associated with administering exogenous fluorescent labels while maintaining diagnostic precision
Solution Approach 2:
The patent enables self-service imaging by utilizing the intrinsic optical properties of biological tissues themselves rather than requiring external fluorescent labels. The galvanometer scanning mirror system captures and processes the natural light scattering and absorption characteristics of tissues, allowing the sample to provide its own contrast mechanism without needing additional labeling agents
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system allows for high-speed imaging of targets within biological tissues by correcting aberrations and increasing the speed of data acquisition, enabling real-time observation and improved resolution beyond the limitations of conventional methods.
Implementation Method 1
a light source emitting a plane wave
Implementation Method 2
an angle-adjustment mirror adjusting an angle of the plane wave emitted from the light source
Implementation Method 3
an optical interferometer dividing the plane wave whose angle was adjusted by the angle-adjustment mirror into a reference wave and a sample wave
Implementation Method 4
forming an interference wave between the reference wave reflected from a reference mirror and the sample wave reflected from the target object
Implementation Method 5
Light waves propagating in a biological tissue experience a wavefront distortion due to difference of speed according to refractive index
Implementation Method 6
Light waves propagating in a biological tissue experience a wavefront distortion due to difference of speed according to refractive index and scattering according to inner structure
Data Source
AI summary
The present invention relates to a high-speed imaging system for measuring a target object within a sample, comprising: a light source emitting a plane wave; an angle-adjustment mirror adjusting an angle of the plane wave emitted from the light source; an optical interferometer dividing the plane wave whose angle was adjusted by the angle-adjustment mirror into a reference wave and a sample wave and forming an interference wave between the reference wave reflected from a reference mirror and the sample wave reflected from the target object; a camera module obtaining the interference wave, and an imaging controller controlling the angle-adjustment mirror to adjust the angle of the plane wave sequentially, forming a time-gated reflection matrix by using the interference waves obtained by the camera module in accordance with each angle of the plane wave, and imaging the target object based on the time-gated reflection matrix.