Ganoderma Lucidum Double-Stranded RNA for Targeted Tumor Suppression
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Solution Overview
Problem
Current cancer treatments using small molecules like alkaloids are often toxic, and macromolecules such as DNA, RNA, and proteins are unstable and have poor activity in living humans, limiting their effectiveness in cancer therapy.
Innovation Solution
A double-stranded RNA molecule, composed of an antisense and sense strand, is derived from Ganoderma lucidum, which can inhibit tumor growth and is used in a pharmaceutical composition for cancer treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If small molecules such as alkaloids are used for cancer treatment, then anticancer efficacy is improved, but toxicity to humans increases
Solution Approach 1:
The invention extracts and utilizes only the beneficial anticancer properties of alkaloids by using double-stranded RNA molecules that specifically target and silence oncogene expression, thereby separating the therapeutic effect from the toxic side effects associated with conventional small molecule alkaloid treatments
Solution Approach 2:
The double-stranded RNA molecules serve as intermediaries that mediate the inhibition of oncogene expression without directly interacting with cellular targets in a toxic manner. The dsRNA molecules specifically bind to and silence oncogene mRNA through RNA interference mechanisms, providing targeted anticancer activity with reduced off-target toxicity
2Adaptability or versatility
If macromolecules such as DNA, RNA, and proteins are used for cancer treatment, then molecular targeting capability is improved, but stability and activity in living humans deteriorate
Solution Approach 1:
The invention modifies the chemical and physical parameters of RNA molecules by forming double-stranded structures with specific configurations. The dsRNA molecules have optimized helical structures, lengths, and sequence compositions that enhance their stability in physiological conditions while maintaining their ability to specifically target oncogene mRNA for silencing
Solution Approach 2:
The invention creates composite double-stranded RNA structures combining sense and antisense strands that work synergistically. The complementary base pairing between strands provides structural stability, while the overall molecular architecture maintains the biological activity needed for specific oncogene targeting and RNA interference-mediated silencing
Data Source
AI summary
Provided are a double-stranded RNA molecule and pharmaceutical use thereof. The RNA is derived from Ganoderma lucidum (Curtis:Fr.) P. Karst., and has a prophylactic and therapeutic effect on tumors.