Ganoderma lucidum mycelium liquid culture beta glucan extraction
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Traditional methods for isolating beta glucans from Ganoderma lucidum harm their bioactivity, and existing products often use dried mushroom powder, where beta glucans are not easily absorbed, reducing the biological efficacy for treating skin diseases like psoriasis and eczema.
Innovation Solution
A production process that encourages mycelium growth to export bioactive compounds like beta glucans into a liquid medium, maintaining their triple helix structure and solubility, allowing for easy absorption and high bioactive efficacy in skin creams.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If traditional extraction process is used to isolate beta glucans, then beta glucans can be obtained, but their bioactivity is harmed and triple helix structure is damaged
Solution Approach 1:
The patent applies extraction by allowing mycelium to naturally export beta glucans into the surrounding liquid culture medium during growth, rather than using harsh chemical extraction methods. This gentle extraction process preserves the triple helix structure and bioactivity of beta glucans while still obtaining them in sufficient quantities for therapeutic use
Solution Approach 2:
The patent changes the physical state parameter of beta glucans from insoluble powder form to soluble form by utilizing the liquid culture medium. This parameter change enhances bioavailability and absorption while maintaining the triple helix structure, as the beta glucans remain in their native conformation during mycelium export into the liquid medium
2Stability of the object's composition
If dried mushroom powder is used as Ganoderma product, then product stability is improved, but beta glucan absorption is reduced and biological efficacy is affected
Solution Approach 1:
The patent changes the solubility parameter of beta glucans from insoluble to soluble by utilizing the liquid culture medium in which mycelium naturally exports them. This soluble form maintains stability while dramatically improving absorption and bioavailability, resolving the contradiction between stability and ease of absorption
Solution Approach 2:
The liquid culture medium acts as an intermediary that facilitates both stability and absorption. It provides a stable environment for beta glucan production while simultaneously serving as a solvent that enables easy absorption, eliminating the need to choose between stability and bioavailability
3Ease of operation
If mycelium is encouraged to export beta glucans into liquid medium, then solubility and absorption are improved, but maintaining triple helix structure becomes challenging
Solution Approach 1:
The mycelium naturally performs the export function into liquid medium as part of its growth process, self-regulating the conditions to maintain triple helix structure. This self-service approach ensures that beta glucans are exported in their bioactive form without requiring external intervention that might damage the structure
Solution Approach 2:
The patent utilizes the specific parameter conditions of the liquid culture medium (pH, temperature, nutrient composition) to enable triple helix structure retention during export. By optimizing these parameters, the system achieves both solubility enhancement and structural preservation simultaneously
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process ensures that over 80% of beta glucans retain their triple helix structure, enhancing their bioactive efficacy and facilitating their absorption, thereby effectively treating skin diseases such as psoriasis and eczema.
Implementation Method 1
The production process encourages the growing mycelium to export bioactive compounds such as beta glucans into the surrounding liquid
Data Source
AI summary
An extract of a liquid culture of Ganoderma lucidum is provided. The production process encourages the growing mycelium to export bioactive compounds such as beta glucans into the surrounding liquid. Thus, the beta glucan is soluble and easily absorbed. More importantly, the production process allows the beta glucan to retain its triple helix structure which is required to maintain a very high bioactive efficacy. The beta glucans from Ganoderma lucidum can be used in a cream for treatment of psoriasis.