Ganoderma Lucidum Polysaccharide Extraction for Insulin Sensitivity

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current treatments for type 2 diabetes mellitus, such as metformin, often come with side effects and require lifestyle changes, necessitating the need for alternative measures to improve insulin sensitivity without toxicity or adverse effects.

Innovation Solution

Administration of a polysaccharide isolated from Ganoderma lucidum with a molecular weight above 135 kDa, containing specific monosaccharides, which is prepared through extraction, precipitation, and fractionation methods, to reduce fasting serum insulin, blood glucose, and insulin resistance levels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If metformin and other anti-diabetic medications are used to stabilize blood glucose levels, then insulin sensitivity is improved, but side effects such as gastric disorders, kidney dysfunction, and liver disease occur

Engineering Contradiction:

Improveinsulin sensitivityVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts the beneficial insulin-sensitizing property from Ganoderma lucidum polysaccharides, isolating and purifying the active component (polysaccharide fraction with molecular weight 135-5364 kDa) that can improve insulin sensitivity without the harmful side effects of synthetic drugs like metformin

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses a natural polysaccharide from Ganoderma lucidum as an alternative to expensive synthetic medications, providing a cost-effective solution that can be administered orally without causing the serious side effects associated with conventional anti-diabetic drugs

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If lifestyle changes are implemented to manage diabetes, then blood glucose control is achieved, but major lifestyle modifications are required

Engineering Contradiction:

Improveblood glucose controlVSAvoidlifestyle changes

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent provides a polysaccharide supplement that can be easily incorporated into the existing diet without requiring major lifestyle changes, allowing individuals to maintain their current lifestyle while achieving blood glucose control through supplementation

Inventive Principle:

Principle #25Self-service

3Reliability

If conventional anti-diabetic treatments are used, then blood glucose levels are stabilized, but treatment compliance is limited due to adverse effects

Engineering Contradiction:

Improveblood glucose stabilizationVSAvoidtreatment compliance

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent offers a natural polysaccharide supplement that is free from the serious side effects of conventional medications, thereby improving treatment compliance and ease of manufacture without compromising blood glucose stabilization

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Data Source

PatentUS9757409B2Method to prepare ganoderma lucidum polysaccharides possessing insulin-sensitizing properties and applications thereof

Publication Date: 2017.09.12 CHANG GUNG BIOTECH

AI summary

The present invention provides a method to prepare polysaccharides from Ganoderma lucidum. The prepared polysaccharides can reduce hyperglycemia and improve insulin sensitivity in humans and animals, and can therefore be used to prevent and treat type 2 diabetes.